(R)-(+)-1-(4-PYRIDYL)ETHANOL

Synonym(s):(R)-(+)-1-(4-Pyridyl)ethanol

CAS NO.：27854-88-2
Empirical Formula: C7H9NO
Molecular Weight: 123.15
MDL number: MFCD00077865
SAFETY DATA SHEET (SDS)
Update Date: 2026-05-28 03:20:42

What is (R)-(+)-1-(4-PYRIDYL)ETHANOL?

Chemical properties

White needles

The Uses of (R)-(+)-1-(4-PYRIDYL)ETHANOL

(1R)-1-(4-Pyridyl)ethanol is a building block reagent used in the synthesis of potent GPR119 receptor agonists used in the treatment of diabetes.

Purification Methods

Purify it by recrystallisation from pet ether. The m recorded after sublimation was 59.9-60.2o, and 55o after crystallisation from *C6H6/pet ether or pet ether/*C6H6. The (-)-di-O-benzoyl tartrate salt has m 146-148o (from EtOH). [UV, ORD: Harelli & Samori J Chem Soc Perkin Trans 2 1462 1974.] The racemate recrystallises from Et2O with m 74-76o,b 90-94o/1mm. The picrate has m 125-126o (from *C6H6). [Ferles & Attia Collect Czech Chem Commun 38 611 1973, UV, NMR: Nielson et al. J Org Chem 29 2898 1964, Beilstein 21 III/IV 522, 21/2 V 217.]

Properties of (R)-(+)-1-(4-PYRIDYL)ETHANOL

Melting point:	67-69 °C(lit.)
Boiling point:	239.7±15.0 °C(Predicted)
Density	1.082±0.06 g/cm3(Predicted)
storage temp.	Inert atmosphere,2-8°C
solubility	soluble in Methanol
form	Crystalline Powder or Needles
pka	13.52±0.20(Predicted)
color	White
optical activity	[α]20/D +55°, c = 1 in chloroform
BRN	4306037

Safety information for (R)-(+)-1-(4-PYRIDYL)ETHANOL

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.