QUINIDINE GLUCONATE

The Uses of QUINIDINE GLUCONATE

Quinidine Gluconate is a salt of Quinidine (Q685000), a dextrorotatory stereoisomer of Quinine. Antiarrhythmic (class IA). Antimalarial.

The Uses of QUINIDINE GLUCONATE

Cardiac depressant (anti-arrhythmic).

Definition

ChEBI: Quinidine D-gluconate is a D-gluconate adduct. It is functionally related to a quinidine.

brand name

Duraquin (Warner Chilcott); Quinaglute (Berlex).

General Description

Quinidinium gluconate(Duraquin, Quinaglute) occurs as an odorless, very bitter,white powder. In contrast with the sulfate salt, it is freelysoluble in water. This is important because there are emergencieswhen the condition of the patient and the need for arapid response make the oral route of administration inappropriate.The high water solubility of the gluconate saltalong with a low irritant potential makes it valuable when aninjectable form is needed in these emergencies. Quinidinegluconate forms a stable aqueous solution. When used for injection, it usually contains 80 mg/mL, equivalent to 50 mgof quinidine or 60 mg of quinidine sulfate.

Veterinary Drugs and Treatments

Quinidine is used in small animal or equine medicine for the treatment of ventricular arrhythmias (VPCs, ventricular tachycardia), refractory supraventricular tachycardias, and supraventricular arrhythmias associated with anomalous conduction in Wolff- Parkinson-White (WPW) syndrome. Chronic use of quinidine for controlling ventricular arrhythmias and supraventricular tachycardia in dogs has diminished over the years as other drugs appear to be more effective. It is still used in dogs and horses to convert atrial fibrillation to sinus rhythm. Oral therapy is generally not used in cats.