Pyrazofurin
Synonym(s):4-Hydroxy-5-β-D-ribofuranosyl-1H-pyrazole-3-carboxamide;Pirazofurin;Pyrazomycin
- CAS NO.：30868-30-5
- Empirical Formula: C9H13N3O6
- Molecular Weight: 259.22
- MDL number: MFCD07995040
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-07-14 16:49:18
What is Pyrazofurin?
The Uses of Pyrazofurin
Geldanamycin (G304500) derivative.
Definition
ChEBI: A C-glycosyl compound that is 4-hydroxy-1H-pyrazole-5-carboxamide in which the hydrogen at position 3 has been replaced by a beta-D-ribofuranosyl group.
Biochem/physiol Actions
Pyrazofurin serves as an effective drug against HIV (human immuno virus), vaccinia virus, West Nile viral infection.
Enzyme inhibitor
This pyrimidine nucleoside (FW = 261.23 g/mol), also known as pyrazomycin, exhibits antineoplastic activity and inhibits cell proliferation and DNA synthesis in cells by inhibiting orotidylate decarboxylase (uridine 5'-phosphate synthase). Pyrazofurin, also known as 3,b-D-ribofuranosyl-4- hydroxypyrazole-5-carboxamide, is the prodrug of the 5’-phosphate derivative. Target(s): adenosylhomocysteinase; 5-aminoimidazole-4- carboxamide-1-b-D-ribofuranosyl 5'-monophosphate formyltransferase; orotate phosphoribosyltransferase; orotidylate decarboxylase, or UMP synthase.
Properties of Pyrazofurin
| Boiling point: | 584.4±50.0 °C(Predicted) |
| Density | 1.785±0.06 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | DMSO, Water (Slightly) |
| pka | 7.17±0.50(Predicted) |
| form | powder |
| color | white to light brown |
| optical activity | [α]/D -49 to -39°, c = 0.5 in H2O |
| Stability: | Hygroscopic |
Safety information for Pyrazofurin
Computed Descriptors for Pyrazofurin
New Products
2-Bromo-4-hydroxypyridine Dibenzoyl-L-tartaric acid Anhydrous (Resolution Reagent) Dibenzo[b,f][1,4]thiazepin-11(10H)-one 1,2,3,9-Tetrahydro-9-Methyl-4H-Carbazole-4-One Cis-Tosylate 1-(4-methoxyphenyl)-4-(4-Nitrophenyl)Piperazine (IT-1) 1-aminocyclobutanecarbonitrile hydrochloride AMINO-O-TOLYL-ACETIC ACID 1-Aminocyclobutanecarboxylic Acid Hydrochloride AMINO(2-BROMOPHENYL)ACETIC ACID 6-BROMOTETRAZOLO[1,5-A]PYRIDINE 3-Oxocyclobutanecarboxylic acid METHANOL-D1(OD) TERTIARY BUTANOL-D9 N-ETHYL-D5-AMINE HYDROCHLORIDE BENZOIC ACID-D CHLOROFORM-D TOLUENE-D3 2-(2-Bromophenyl)ethanol Boc-D-Glu(OMe)-OMe 2,5 Dibromopyridine Ethyl 4-hydroxy-3-oxobutanoate Dimethyl (2S)-2-((tert-butoxycarbonyl)amino)-4-(cyanomethyl)pentanedioate 1-(3-Chlorophenyl)piperazine hydrochlorideRelated products of tetrahydrofuran
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