propoxycaine

Toxicity

The toxicity of this medication (7-8 times higher than that of procaine), has prevented this medication from being used on its own .
Ester-type local anesthetics are much more likely to cause an allergic reaction compared to the amide-group local anesthetics because of the formation of PABA (Para-aminobenzoic acid) during the metabolic process. PABA may cause allergic reactions that range from urticaria to anaphylaxis. PABA is also formed during the metabolism of methylparaben (a common preservative) that is normally found in multi-dose vials including lidocaine (MDV) (amide-type local anesthetic) .

The Uses of propoxycaine

Anesthetic (local) Blockain.

Indications

Propoxycaine is a local anesthetic medication. It was used beginning in the 1950s during dental procedures . It has been combined with procaine to accelerate its onset of action and provide longer-lasting anesthetic effect .
It was produced for use when amide local anesthetics were contraindicated due to allergy or when several amide anesthetics were unsuccessful .

Background

Propoxycaine is a local anesthetic of the ester type that has a rapid onset of action and a longer duration of action than procaine hydrochloride . This drug was removed from the US market in 1996. Although no longer available in the United States, this medication was used in combination with procaine to aid in anesthesia during dental procedures . Used in combination with procaine, it was the only dental local anesthetic available in cartridge form .

Definition

ChEBI: Propoxycaine is a benzoate ester.

brand name

Hydrochloride (Sterling Winthrop); Ravocaine Hydrochloride (Cook-Waite).

Pharmacokinetics

Propoxycaine is a local anesthetic which acts to decrease nerve impulses and therefore pain sensation during dental procedures .

Metabolism

This drug his hydrolyzed in both the plasma and the liver by plasma esterases .