propiomazine

Toxicity

Although rare, serious adverse events may be seen with propiomazine. Such events include convulsions (seizures), difficult or unusually fast breathing, fast or irregular heartbeat or pulse, fever (high), high or low blood pressure, loss of bladder control, muscle stiffness (severe), unusual increase in sweating, unusually pale skin, and unusual tiredness or weakness.

The Uses of propiomazine

Propiomazine is used in the preparation of analgesics as well as maintaining its own analgesic effects whilst applied to various neurological diseases.

The Uses of propiomazine

1-[10-[2-(Dimethylamino)propyl]phenothiazin-2-yl-1-propanone is used in the preparation of analgesics as well as maintaining its own analgesic effects whilst applied to various neurological diseases.

Background

Propiomazine, an atypical antipsychotic agent, is used to treat both negative and positive symptoms of schizophrenia, acute mania with bipolar disorder, agitation, and psychotic symptoms in dementia. Future uses may include the treatment of obsessive-compulsive disorder and severe behavioral disorders in autism. Structurally and pharmacologically similar to clozapine, propiomazine binds to alpha(1), dopamine, histamine H1, muscarinic, and serotonin type 2 (5-HT2) receptors.

Indications

Propiomazine is largely used for its antihistamininc sleep inducing effects in treating insomnia.

Definition

ChEBI: A member of the class of phenothiazines that is 10H-phenothiazine substituted by a 2-(dimethylamino)propyl group at nitrogen atom and a propanoyl group at position 2.

brand name

Largon (Baxter Healthcare).

Pharmacokinetics

Although propiomazine is a phenothiazine, it is not used as an antipsychotic. It posesses antihistamine effects and is mostly used as a sedative in treating insomnia.

Metabolism

Unknown, but most likely hepatic as with other phenothiazines.