CHEMICAL AND PHYSICAL PROPERTIES
| Physical Description | Solid |
|---|---|
| Boiling Point | 235-245 °C @ 0.5 MM HG |
| Melting Point | MP: 160-161 °C; CRYSTALS FROM ISOPROPANOL /MALEATE/ |
| Solubility | 0.454 mg/L |
| LogP | 4.79 |
| Kovats Retention Index | 2736 2740 2738 2738 2720 2740 2738 2759.3 |
| Other Experimental Properties | PRACTICALLY ODORLESS; YELLOW POWDER /HYDROCHLORIDE/ |
COMPUTED DESCRIPTORS
| Molecular Weight | 340.5 g/mol |
|---|---|
| XLogP3 | 4.8 |
| Hydrogen Bond Donor Count | 0 |
| Hydrogen Bond Acceptor Count | 4 |
| Rotatable Bond Count | 5 |
| Exact Mass | 340.16093457 g/mol |
| Monoisotopic Mass | 340.16093457 g/mol |
| Topological Polar Surface Area | 48.8 Ų |
| Heavy Atom Count | 24 |
| Formal Charge | 0 |
| Complexity | 441 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 1 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 1 |
| Compound Is Canonicalized | Yes |
PRODUCT INTRODUCTION
description
Propiomazine is a member of the class of phenothiazines that is 10H-phenothiazine substituted by a 2-(dimethylamino)propyl group at nitrogen atom and a propanoyl group at position 2. It has a role as a phenothiazine antipsychotic drug, a dopaminergic antagonist, a serotonergic antagonist, a muscarinic antagonist, a histamine antagonist and a sedative. It is a member of phenothiazines, an aromatic ketone and a tertiary amino compound. It derives from a hydride of a 10H-phenothiazine.