Proguanil hydrochloride
- CAS NO.：537-21-3
- Empirical Formula: C11H15Cl2N5
- Molecular Weight: 288.18
- MDL number: MFCD01732193
- EINECS: 208-660-3
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-09-12 18:51:19
What is Proguanil hydrochloride?
The Uses of Proguanil hydrochloride
PROGUANIL HYDROCHLORIDE is an antimalarial agent used in combination with Dapsone (D193250).
Definition
ChEBI: Chlorproguanil is a dichlorobenzene.
Clinical Use
Malaria chemoprophylaxis
Drug interactions
Potentially hazardous interactions with other drugs
Anticoagulants: effect of warfarin possibly enhanced.
Antimalarials: avoid concomitant use with
artemether/lumefantrine; increased antifolate effect
with pyrimethamine.
Metabolism
Proguanil is metabolised in the liver to the active metabolite, cycloguanil, and to p-chlorophenylbiguanide which is inactive, mainly by cytochrome P450, CYP 2C19 and slightly by CYP 3A4. Unlike proguanil and p-chlorophenylbiguanide, cycloguanil is not concentrated in erythrocytes so concentrations of cycloguanil in plasma and whole blood are similar. About 40-60% of a dose of proguanil is excreted in the urine, 60% of this as the unchanged drug, 30% as cycloguanil, and 8% as p-chlorophenylbiguanide. About 10% of a dose is excreted in the faeces.
Properties of Proguanil hydrochloride
| Melting point: | 120-121 °C |
| Boiling point: | 350.7±52.0 °C(Predicted) |
| Density | 1.40±0.1 g/cm3(Predicted) |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 10.77±0.10(Predicted) |
| color | White to Off-White |
| Stability: | Hygroscopic |
Safety information for Proguanil hydrochloride
Computed Descriptors for Proguanil hydrochloride
New Products
9-Mesityl-10-methylacridinium perchlorate Sulfapyridine Fmoc-OSu (R)-(-)-2-Amino-1-propanol Cyclobutanone 5-bromo-4-fluoro-2-nitrobenzaldehyde 4 pentyn 1 ol N-Vinylformamide Phenethyl cinnamate Pyrrolo[1,2-a]pyrimidine-6-carboxylic acid, 4,6,7,8-tetrahydro-4-oxo-, sodium salt (1:1), (6S) Ethyl 3-phenylpropanoate β-Bromostyrene Methacrylate-PEG-Methacrylate, Mn:35000 2,4-Dihydroxyacetophenone 2-Chloro 5-Fluoro Pyridine Vasicinone 2-Chloroisonicotinic Acid Tween 80 or Polysorbate 80 5-Bromo-1-Pentyne 1-(2-Methyl-5-nitrophenyl)guanidine Nitrate Methyl trans-4-Aminocyclohexanecarboxylate Hydrochloride 2-Pentyn-1-oL 4-Nitrobenzotrifluoride N-(4-Cyano-3-(trifluoromethyl)phenyl)-2-methyloxirane-2-carboxamideRelated products of tetrahydrofuran
You may like
-
1191-95-3 Cyclobutanone 98+View Details
1191-95-3 -
213382-45-7 98+View Details
213382-45-7 -
Fmoc-OSu 98+View Details
82911-69-1 -
(R)-(-)-2-Amino-1-propanol 35320-23-1 98+View Details
35320-23-1 -
1191-95-3 Cyclobutanone 98+View Details
1191-95-3 -
213382-45-7 98+View Details
213382-45-7 -
Fmoc-OSu 98+View Details
82911-69-1 -
(R)-(-)-2-Amino-1-propanol 35320-23-1 98+View Details
35320-23-1