4-CHLOROPHENYLGUANIDINE HYDROCHLORIDE
- CAS NO.：14279-91-5
- Empirical Formula: C7H9Cl2N3
- Molecular Weight: 206.07
- MDL number: MFCD00209839
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-03-13 23:13:44
What is 4-CHLOROPHENYLGUANIDINE HYDROCHLORIDE?
The Uses of 4-CHLOROPHENYLGUANIDINE HYDROCHLORIDE
p-Chlorophenylguanidine Hydrochloride is an reagent used in the synthesis of pyrimidine derivatives as hSMG-1 inhibitors, potential targets for cancer treatment.
What are the applications of Application
4-Chlorophenylguanidine hydrochloride is a specific and potent inhibitor of urokinase
Biological Activity
4-chlorophenylguanidine hydrochloride is a potent and selective inhibitor of urokinase [1].urokinase is a serine protease. its primary physiological substrate is plasminogen, which is an inactive form of plasmin. urokinase plays an important role in vascular diseases and cancer.4-chlorophenylguanidine hydrochloride inhibited urokinase and trypsin with ki value of 6.07 μm and 120 μm, respectively [1].
Storage
Store at RT
References
[1]. yang h, henkin j, kim kh, et al. selective inhibition of urokinase by substituted phenylguanidines: quantitative structure-activity relationship analyses. j med chem, 1990, 33(11): 2956-2961.
Properties of 4-CHLOROPHENYLGUANIDINE HYDROCHLORIDE
| Melting point: | 237-238 °C(Solv: water (7732-18-5)) |
| storage temp. | Store at RT |
| solubility | DMSO (Slightly), Methanol (Slightly), Water (Slightly) |
| form | Solid |
| color | White to Pale Green |
| Water Solubility | Soluble to 100 mM in water |
Safety information for 4-CHLOROPHENYLGUANIDINE HYDROCHLORIDE
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 4-CHLOROPHENYLGUANIDINE HYDROCHLORIDE
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