Cycloguanil
- CAS NO.：516-21-2
- Empirical Formula: C11H14ClN5
- Molecular Weight: 251.72
- MDL number: MFCD00838855
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-05-28 01:13:29
What is Cycloguanil?
Description
Cycloguanil was first observed in 1951 as a metabolite of the antimalarial drug chlorguanide; it also has shown activity against malaria. Because traditional antimalarials are becoming ineffective against new strains of the malarial protozoan Plasmodium falciparum, renewed efforts are underway to develop cycloguanil into a commercial drug.
The Uses of Cycloguanil
Antimalarial.
Background
Cycloguanil is the active metabolite of proguanil.
Definition
ChEBI: Cycloguanil is a triazine in which a 1,6-dihydro-1,3,5-triazine ring is substituted at N-1 by a 4-chlorophenyl group, at C-2 and -4 by amino groups and at C-6 by gem-dimethyl groups. A dihydrofolate reductase inhibitor, it is a metabolite of the antimalarial drug proguanil. It has a role as an EC 1.5.1.3 (dihydrofolate reductase) inhibitor, an antiinfective agent, an antiparasitic agent, an antimalarial, an antiprotozoal drug and an antifolate.
Metabolism
Not Available
Properties of Cycloguanil
| Melting point: | 146° |
| Boiling point: | 397.13°C (rough estimate) |
| Density | 1.2332 (rough estimate) |
| refractive index | 1.6110 (estimate) |
| storage temp. | Store at -20°C |
| solubility | Soluble in DMSO |
| form | Solid |
| color | White to off-white |
Safety information for Cycloguanil
Computed Descriptors for Cycloguanil
New Products
Cis-Tosylate Dibenzoyl-L-tartaric acid Anhydrous (Resolution Reagent) 2,6-Dipicolic Acid 1,2,3,9-Tetrahydro-9-Methyl-4H-Carbazole-4-One Dibenzo[b,f][1,4]thiazepin-11(10H)-one N-BOC-piperidine-4-carboxylic acid 1-Benzhydrylazetane-3-carbonitrile AMINO-(3-CHLORO-PHENYL)-ACETIC ACID 2-(2-Chlorophenyl)glycine (±)-amino(2-fluorophenyl)acetic acid 8-oxa-1,3-diazaspiro[4.5]decane-2,4-dione MEHYL AMINE-D3.HCL METHANE SULFONIC ACID-D4 PHOSPORIC ACID-D3 85 W% IN D2O DEUTERIUM OXIDE FOR NMR TOLUENE-D3 BENZENE-D6 1-(3-Chlorophenyl)piperazine hydrochlorideRelated products of tetrahydrofuran
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