Cycloguanil
- CAS NO.：516-21-2
- Empirical Formula: C11H14ClN5
- Molecular Weight: 251.72
- MDL number: MFCD00838855
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-03-18 11:52:23
What is Cycloguanil?
Description
Cycloguanil was first observed in 1951 as a metabolite of the antimalarial drug chlorguanide; it also has shown activity against malaria. Because traditional antimalarials are becoming ineffective against new strains of the malarial protozoan Plasmodium falciparum, renewed efforts are underway to develop cycloguanil into a commercial drug.
The Uses of Cycloguanil
Antimalarial.
Background
Cycloguanil is the active metabolite of proguanil.
Definition
ChEBI: Cycloguanil is a triazine in which a 1,6-dihydro-1,3,5-triazine ring is substituted at N-1 by a 4-chlorophenyl group, at C-2 and -4 by amino groups and at C-6 by gem-dimethyl groups. A dihydrofolate reductase inhibitor, it is a metabolite of the antimalarial drug proguanil. It has a role as an EC 1.5.1.3 (dihydrofolate reductase) inhibitor, an antiinfective agent, an antiparasitic agent, an antimalarial, an antiprotozoal drug and an antifolate.
Metabolism
Not Available
Properties of Cycloguanil
| Melting point: | 146° |
| Boiling point: | 397.13°C (rough estimate) |
| Density | 1.2332 (rough estimate) |
| refractive index | 1.6110 (estimate) |
| storage temp. | Store at -20°C |
| solubility | Soluble in DMSO |
| form | Solid |
| color | White to off-white |
Safety information for Cycloguanil
Computed Descriptors for Cycloguanil
New Products
2,6-Piperidinedione, 3-hydroxy-1-[(4-methoxyphenyl)methyl]- 3-(4-bromo-3-methyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidine-2,6-dione 4-Hydroxy-6-methyl-1-(4-methylphenyl)-2-naphthalenecarboxylic acid 2,3-Difluoro-6-methoxybenzyl Chloride KT-474 2-(6-(benzyloxy)-3,4-dihydronaphthalen-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 3-Oxocyclobutanecarboxylic acid 5-Bromo-2-iodo pyridine Benzofuran-6-carboxylic acid (BFA) 3-Bromo-2-Ethoxy-5-Nitropyridine 3,6-Dichloro-2-Methylpyridine 2-Amino-5-Bromo-3-IodopyridineRelated products of tetrahydrofuran
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