Progabide

CAS NO.：62666-20-0
Empirical Formula: C17H16ClFN2O2
Molecular Weight: 334.77
MDL number: MFCD01740869
EINECS: 263-679-4
SAFETY DATA SHEET (SDS)
Update Date: 2026-06-03 11:24:09

What is Progabide?

Description

Progabide is a broad-spectrum anticonvulsant agent indicated for the treatment of a wide variety of seizure disorders. Synthesized as a GABA-prodrug, anticonvulsant activity appears due to the parent drug and its acid metabolite, as well as to GABAmide and GABA liberated therefrom.

Chemical properties

Bright Yellow Solid

Originator

Synthelabo (France)

The Uses of Progabide

Progabide is a gamma-aminobutyric acid (GABA) antagonist with antiepileptic activity.

What are the applications of Application

Progabide is a GABAA and GABAB receptor agonistic

Definition

ChEBI: Progabide is a diarylmethane.

brand name

Gabren (Synthelabo Pharmacie, France);Gabaphore;Sl 76 002;GABRENE.

World Health Organization (WHO)

Progabide, an anticonvulsant, was introduced in France in 1985 for the treatment of epilepsy. Its use has occasionally been associated with clinically evident signs of icteric hepatitis developing within the first six months of treatment. These signs are generally reversible on withdrawal of the drug but continuation of treatment has been associated with three reported fatalities (two of which are doubtfully related to the drug). The manufacturer revised the data sheet in March 1986 advising that use of progabide should be reserved for patients unresponsive to other anticonvulsants.

Properties of Progabide

Melting point:	133-135°; mp 142.5° (Kaplan, J. Med. Chem.)
Boiling point:	525.4±50.0 °C(Predicted)
Density	1.2822 (estimate)
storage temp.	2-8°C
solubility	Chloroform (Slightly, Sonicated), DMSO, Methanol (Slightly, Sonicated)
form	Solid
pka	pKa 3.41 ± 0.04(0.4% MeOH,t=37,Iundefined)(Approximate)
color	Light Yellow to Yellow
Water Solubility	37.16mg/L(37 ºC)
CAS DataBase Reference	62666-20-0

Safety information for Progabide

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.