Poziotinib (HM781-36B)
- CAS NO.：1092364-38-9
- Empirical Formula: C23H21Cl2FN4O3
- Molecular Weight: 491.34
- MDL number: MFCD28044290
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-07-14 16:49:18
What is Poziotinib (HM781-36B)?
Description
Poziotinib is a TKI that covalently and irreversibly inhibits EGFR and HER2, and is unique because of its small terminal group and flexible quinazoline core. Its small size and flexibility allow it to evade the steric hindrance which affects other EGFR TKIs [138].
The Uses of Poziotinib (HM781-36B)
Poziotinib can be used to inhibit the growth of cancer cells.
Properties of Poziotinib (HM781-36B)
| Melting point: | 187 - 190° C |
| Boiling point: | 629.7±55.0 °C(Predicted) |
| Density | 1.409±0.06 g/cm3(Predicted) |
| storage temp. | -20°C Freezer, Under inert atmosphere |
| solubility | Chloroform (Slightly), DMSO (Slightly, Sonicated) |
| form | Solid |
| pka | 5.35±0.30(Predicted) |
| color | White to Pale Beige |
| CAS DataBase Reference | 1092364-38-9 |
Safety information for Poziotinib (HM781-36B)
Computed Descriptors for Poziotinib (HM781-36B)
New Products
Dibenzoyl-L-tartaric acid Anhydrous (Resolution Reagent) Cis-Tosylate Dibenzo[b,f][1,4]thiazepin-11(10H)-one 1,2,3,9-Tetrahydro-9-Methyl-4H-Carbazole-4-One 1-(4-methoxyphenyl)-4-(4-Nitrophenyl)Piperazine (IT-1) BOC Piperazine 1-Benzhydrylazetane-3-carbonitrile 8-oxa-1,3-diazaspiro[4.5]decane-2,4-dione (±)-amino(2-fluorophenyl)acetic acid 2-(2-Chlorophenyl)glycine AMINO-(3-CHLORO-PHENYL)-ACETIC ACID 2'-Fluoroacetophenone METHANOL-D1(OD) TERTIARY BUTANOL-D9 N-ETHYL-D5-AMINE HYDROCHLORIDE BENZOIC ACID-D CHLOROFORM-D TOLUENE-D3 Trans,trans muconic acid HC Blue-16 4-Amino-2-chloro-6,7-dimethoxyquinazoline Ethyl 4,5-bis(2-methoxyethoxy)-2-nitrobenzoate 2,3-Dimethoxypyridine 1-(3-Chlorophenyl)piperazine hydrochlorideRelated products of tetrahydrofuran
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