PD168393
Synonym(s):4-[(3-Bromophenyl)amino]-6-acrylamidoquinazoline;4-[(3-Bromophenyl)amino]-6-acrylamidoquinazoline; N-[4-[(3-Bromophenyl)amino]-6-quinazolinyl]-2-propenamide;PD 168393;PD 168393 - CAS 194423-15-9 - Calbiochem
- CAS NO.：194423-15-9
- Empirical Formula: C17H13BrN4O
- Molecular Weight: 369.22
- MDL number: MFCD02179207
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-07-27 17:00:41
What is PD168393?
The Uses of PD168393
PD168393 has been used in the acute inhibition of ErbB4.
The Uses of PD168393
PD 168393, is an irreversible epidermal growth factor receptor (EGFR) inhibitor.
What are the applications of Application
PD 168393 is a potent, cell-permeable, irreversible inhibitor of EGFR
Definition
ChEBI: A member of the class of quinazolines carrying bromoanilino and acrylamido substituents at positions 4 and 6 respectively.
Biochem/physiol Actions
PD168393 is a 6-acrylamido-4-anilinoquinazoline compound. It increases apoptosis in malignant peripheral nerve sheath tumor cells, stimulated by lysosomal dysfunction.
Properties of PD168393
| Melting point: | 279℃ |
| Boiling point: | 571.1±50.0 °C(Predicted) |
| Density | 1.558±0.06 g/cm3(Predicted) |
| storage temp. | room temp |
| solubility | insoluble in H2O; ≥1 mg/mL in EtOH with gentle warming and ultrasonic; ≥18.45 mg/mL in DMSO |
| form | powder |
| pka | 12.19±0.43(Predicted) |
| color | white to beige |
Safety information for PD168393
Computed Descriptors for PD168393
New Products
9-Mesityl-10-methylacridinium perchlorate Sulfapyridine Fmoc-OSu (R)-(-)-2-Amino-1-propanol Cyclobutanone 5-bromo-4-fluoro-2-nitrobenzaldehyde 4 pentyn 1 ol N-Vinylformamide Phenethyl cinnamate Pyrrolo[1,2-a]pyrimidine-6-carboxylic acid, 4,6,7,8-tetrahydro-4-oxo-, sodium salt (1:1), (6S) Ethyl 3-phenylpropanoate β-Bromostyrene Methacrylate-PEG-Methacrylate, Mn:35000 2,4-Dihydroxyacetophenone 2-Chloro 5-Fluoro Pyridine Vasicinone 2-Chloroisonicotinic Acid Tween 80 or Polysorbate 80 5-Bromo-1-Pentyne 1-(2-Methyl-5-nitrophenyl)guanidine Nitrate Methyl trans-4-Aminocyclohexanecarboxylate Hydrochloride N-(4-Cyano-3-(trifluoromethyl)phenyl)-2-methyloxirane-2-carboxamide 4-Nitrobenzotrifluoride 2-Pentyn-1-oLRelated products of tetrahydrofuran
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