Ponesterone A

Synonym(s):2β,3β,14α,20R,22R-Pentahydroxy-5β-cholest-7-en-6-one;25-Deoxy-20-hydroxyecdysone;25-Deoxyecdysterone

CAS NO.：13408-56-5
Empirical Formula: C27H44O6
Molecular Weight: 464.63
MDL number: MFCD00272144
SAFETY DATA SHEET (SDS)
Update Date: 2025-10-12 12:02:55

What is Ponesterone A?

Description

Ponesterone A, a steroidal compound, falls under the category of ecdysone and can be found in various sources throughout nature. It was first isolated from insect plants by Nakanishi and Horm in 1966. Compared to β-ecdysone, Ponesterone proves to be 3-100 times more potent in specific neurosensory systems.

The Uses of Ponesterone A

Ponasterone A is an Ecdysone analog.

The Uses of Ponesterone A

Ponasterone A has been used to induce the expression of human huntingtin (HTT).

What are the applications of Application

Ponasterone A is an insect steroid hormone analog that can regulate the metamorphosis of Drosphila.

Definition

ChEBI: Ponasterone A is a 2beta-hydroxy steroid, a 3beta-hydroxy steroid, a 14alpha-hydroxy steroid, a 20-hydroxy steroid, a 22-hydroxy steroid, a 6-oxo steroid and a phytoecdysteroid.

Biochem/physiol Actions

Ponasterone A is an analogue of ecdysone. It induced death of non-adapted insects may be related to PoA regulating different set of genes when compared to 20E.

Storage

+4°C

Properties of Ponesterone A

Melting point:	259-260° (dec)
Boiling point:	640.5±55.0 °C(Predicted)
alpha	D15 +90° (methanol)
Density	1.22±0.1 g/cm3(Predicted)
storage temp.	−20°C
solubility	Methanol (Slightly, Sonicated), Pyridine (Slightly)
form	White to off-white powder.
pka	14.13±0.70(Predicted)
color	White to Off-White
CAS DataBase Reference	13408-56-5(CAS DataBase Reference)