Pomalidomide-PEG3-CO2H

Synonym(s):3-(2-(2-(2-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)ethoxy)ethoxy)propanoic acid;Crosslinker−E3 Ligase ligand conjugate;Protein degrader building block for PROTAC research;Template for synthesis of targeted protein degrader

CAS NO.：2138440-82-9
Empirical Formula: C22H27N3O9
Molecular Weight: 477.46
MDL number: MFCD32173779
Update Date: 2026-03-13 15:00:32

What is Pomalidomide-PEG3-CO2H?

The Uses of Pomalidomide-PEG3-CO2H

Protein degrader builiding block Pomalidomide-PEG₃-CO₂H enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a Cereblon (CRBN)-recruiting ligand and a PEGylated crosslinker with pendant carboxylic acid for reactivity with an amine on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant carboxyl group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.

Storage

Store at -20°C

Properties of Pomalidomide-PEG3-CO2H

Boiling point:	757.8±60.0 °C(Predicted)
Density	1.417±0.06 g/cm3(Predicted)
storage temp.	2-8°C
solubility	Soluble in DMSO
pka	4.28±0.10(Predicted)
form	Solid
color	Light yellow to green yellow