POMALIDOMIDE-PEG1-CO2H
Synonym(s):3-(2-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)propanoic acid;Crosslinker–E3 Ligase ligand conjugate;Protein degrader building block for PROTAC research;Template for synthesis of targeted protein degrader
- CAS NO.：2139348-60-8
- Empirical Formula: C18H19N3O7
- Molecular Weight: 389.36
- MDL number: MFCD32063496
- Update Date: 2026-01-13 11:14:16
What is POMALIDOMIDE-PEG1-CO2H?
The Uses of POMALIDOMIDE-PEG1-CO2H
Protein degrader builiding block Pomalidomide-PEG1-CO2H enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a Cereblon (CRBN)-recruiting ligand and a PEGylated crosslinker with pendant carboxylic acid for reactivity with an amine on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant carboxyl group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.
Storage
Store at -20°C
Properties of POMALIDOMIDE-PEG1-CO2H
| Boiling point: | 726.2±60.0 °C(Predicted) |
| Density | 1.508±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| form | powder or crystals |
| pka | 4.29±0.10(Predicted) |
| color | Yellow to brown |
Safety information for POMALIDOMIDE-PEG1-CO2H
Computed Descriptors for POMALIDOMIDE-PEG1-CO2H
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