PNU 100480

Synonym(s):(S)-N-[[3-[3-Fluoro-4-(4-thiomorpholinyl)phenyl]-2-oxo-5-oxazolidinyl]methyl]-acetamide;PNU100480;PNU-100480

CAS NO.：168828-58-8
Empirical Formula: C16H20FN3O3S
Molecular Weight: 353.41
MDL number: MFCD00937821
SAFETY DATA SHEET (SDS)
Update Date: 2026-04-16 19:33:17

What is PNU 100480?

Description

PNU 100480 is an oxazolidinone antibiotic that is active against multidrug resistant tuberculosis. It inhibits the growth of M. tuberculosis replicating and nonreplicating strains (MIC = ~400 ng/ml for both) and of clinical isolates that are susceptible or resistant to a combination of isoniazid , rifampin (rifampicin; ), ethambutol , and streptomycin (; MICs = ≤0.0625-0.5 mg/L). It also inhibits the growth of P. insidiosum and P. aphanidermatum clinical isolates (MICs = 4-64 μg/ml). PNU 100480 (100 mg/kg per day) decreases the number of colony forming units (CFU) in the lung in a mouse model of systemic nonreplicating M. tuberculosis infection.

The Uses of PNU 100480

Sutezolid is an oxazolidinone antibacterial agent analog. Sutezolid is a promising antimycobacterial agent (tuberculostatic).

Biochem/physiol Actions

Sutezolid (PNU 100480) is an oxazolidinone antimicrobial. Sutezolid inhibits protein synthesis by inhibiting bacterial mRNA translation. Sutezolid is being investigated for the treatment of multiple drug–resistant and extensively drug-resistant tuberculosis. The compound is a less toxic and more potent derivative of linezolid.

Properties of PNU 100480

Melting point:	186-187°C
Boiling point:	609.0±55.0 °C(Predicted)
Density	1.321±0.06 g/cm3(Predicted)
storage temp.	room temp
solubility	DMSO: soluble20mg/mL, clear
form	powder
pka	15.53±0.46(Predicted)
color	white to beige
optical activity	[α]/D -8 to -12°, c = 1 in chloroform-d

Safety information for PNU 100480

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral
Precautionary Statement Codes	P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.