PF-04995274
- CAS NO.：1331782-27-4
- Empirical Formula: C23H32N2O6
- Molecular Weight: 432.51
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-05-28 04:44:15
What is PF-04995274?
Description
PF-04995274 is a partial agonist of the serotonin (5-HT) receptor subtypes 5-HT4A, 5-HT4B, 5-HT4D, and 5-HT4E (Kis = 0.36, 0.46, 0.15, and 0.32 nM, respectively, in a radioligand binding assay). It increases cAMP levels in HEK293 cells expressing 5-HT4A, 5-HT4B, 5-HT4D, and 5-HT4E receptors (EC50s = 0.47, 0.36, 0.37, and 0.26 nM, respectively, for the human recombinant receptors). PF-04995274 decreases scopolamine-induced increases in the distance traveled in the Morris water maze in rats when administered at a dose of 0.032 mg/kg.
Properties of PF-04995274
| storage temp. | Store at -20°C |
| solubility | DMSO:20.0(Max Conc. mg/mL);46.2(Max Conc. mM) |
| form | A crystalline solid |
| color | White to off-white |
Safety information for PF-04995274
Computed Descriptors for PF-04995274
New Products
3-AMINO-3-(2-FLUORO-PHENYL)-PROPIONIC ACID Pentadecanoic acid Hendecanoic acid 2-AMINO-3-METHYLQUINOLINE HYDROCHLORIDE 3-Hydroxypropionitrile DL-3-Amino-3-(2-methoxyphenyl)propionic acid 2-Bromo-5-Iodopyridine 2,3-Diamino-5-Chloropyridine 2-Amino-3-Hydroxypyridine 2,6-Diamino Pyridine 4-Amino-2-Chloropyridine 2-Hydroxy-4-Picoline 4-(4-(Dimethylamino)-1-(4-fluorophenyl)-1-hydroxybutyl)-3-(hydroxymethyl)benzonitrile 2-Hydroxy-5-methoxybenzoic acid 2-Cyanopyrimidine Xanthene-9-carboxylic acid 4,4-Diethoxybutanenitrile Methyl 4-amino-2,3-difluoro-5-nitrobenzoate 5-fluoro-1,3-benzodioxole 5-Phenyl-[1,3,4]-thiadiazol-2-amine 2-Chloro-6-nitro benzothiazole 4-Chloro-2-methyl quinoline 2-Amino-4-phenyl-thiazole 2-(Chloromethyl) quinazolin-4(3H)-oneRelated products of tetrahydrofuran
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