PF 04995274
- CAS NO.：1331782-27-4
- Empirical Formula: C23H32N2O6
- Molecular Weight: 432.51
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-04-17 13:05:51
What is PF 04995274?
Description
PF-04995274 is a partial agonist of the serotonin (5-HT) receptor subtypes 5-HT4A, 5-HT4B, 5-HT4D, and 5-HT4E (Kis = 0.36, 0.46, 0.15, and 0.32 nM, respectively, in a radioligand binding assay). It increases cAMP levels in HEK293 cells expressing 5-HT4A, 5-HT4B, 5-HT4D, and 5-HT4E receptors (EC50s = 0.47, 0.36, 0.37, and 0.26 nM, respectively, for the human recombinant receptors). PF-04995274 decreases scopolamine-induced increases in the distance traveled in the Morris water maze in rats when administered at a dose of 0.032 mg/kg.
Properties of PF 04995274
| storage temp. | Store at -20°C |
| solubility | DMSO:20.0(Max Conc. mg/mL);46.2(Max Conc. mM) |
| form | A crystalline solid |
| color | White to off-white |
Safety information for PF 04995274
Computed Descriptors for PF 04995274
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