PMPA(NAALADaseinhibitor)
Synonym(s):2-(Phosphonomethyl)-pentandioic acid;2-Phosphonomethyl pentanedioic acid;PMPA
- CAS NO.：173039-10-6
- Empirical Formula: C6H11O7P
- Molecular Weight: 226.12
- MDL number: MFCD00940167
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-03-17 20:01:48
What is PMPA(NAALADaseinhibitor)?
The Uses of PMPA(NAALADaseinhibitor)
2-(Phosphonomethyl)pentanedioic Acid is a selective glutamate carboxypeptidase 2 (GCP-II) inhibitor, the enzyme which catabolizes the abundant neuropeptide N-acetyl-aspartyl-glutamate (NAAG) to N-acetylaspartate (NAA) and glutamate. A posiible target in the treatment of multiple sclerosis and Schizophrenia.
What are the applications of Application
2-(Phosphonomethyl)-pentanedioic acid is an inhibitor of the neuropeptidase NAALADase
Biological Activity
Highly potent and selective inhibitor of? glutamate carboxypeptidase 2 (GCP II/N-acetylated α -linked dipeptidase/NAALADase) with a K i value of 275 pM. Neuroprotective; protects against glutamate-mediated motor neuron degeneration and reduces volume of injury following middle cerebral artery occlusion (MCAO).
Biochem/physiol Actions
2-PMPA is a potent and selective inhibitor of Glutamate carboxypeptidase II (GCPII).
Storage
Desiccate at RT
Properties of PMPA(NAALADaseinhibitor)
| Boiling point: | 538.8±60.0 °C(Predicted) |
| Density | 1.658±0.06 g/cm3(Predicted) |
| storage temp. | room temp |
| solubility | Soluble to 100 mM in sterile |
| pka | 2.06±0.10(Predicted) |
| form | powder |
| color | white to beige |
| Water Solubility | Soluble to 100 mM in water |
Safety information for PMPA(NAALADaseinhibitor)
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation |
| Precautionary Statement Codes |
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for PMPA(NAALADaseinhibitor)
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