PMPA(NAALADaseinhibitor)

Synonym(s):2-(Phosphonomethyl)-pentandioic acid;2-Phosphonomethyl pentanedioic acid;PMPA

CAS NO.：173039-10-6
Empirical Formula: C6H11O7P
Molecular Weight: 226.12
MDL number: MFCD00940167
SAFETY DATA SHEET (SDS)
Update Date: 2025-12-17 11:34:44

What is PMPA(NAALADaseinhibitor)?

The Uses of PMPA(NAALADaseinhibitor)

2-(Phosphonomethyl)pentanedioic Acid is a selective glutamate carboxypeptidase 2 (GCP-II) inhibitor, the enzyme which catabolizes the abundant neuropeptide N-acetyl-aspartyl-glutamate (NAAG) to N-acetylaspartate (NAA) and glutamate. A posiible target in the treatment of multiple sclerosis and Schizophrenia.

What are the applications of Application

2-(Phosphonomethyl)-pentanedioic acid is an inhibitor of the neuropeptidase NAALADase

Biological Activity

Highly potent and selective inhibitor of? glutamate carboxypeptidase 2 (GCP II/N-acetylated α -linked dipeptidase/NAALADase) with a K i value of 275 pM. Neuroprotective; protects against glutamate-mediated motor neuron degeneration and reduces volume of injury following middle cerebral artery occlusion (MCAO).

Biochem/physiol Actions

2-PMPA is a potent and selective inhibitor of Glutamate carboxypeptidase II (GCPII).

Storage

Desiccate at RT

Properties of PMPA(NAALADaseinhibitor)

Boiling point:	538.8±60.0 °C(Predicted)
Density	1.658±0.06 g/cm3(Predicted)
storage temp.	room temp
solubility	Soluble to 100 mM in sterile
pka	2.06±0.10(Predicted)
form	powder
color	white to beige
Water Solubility	Soluble to 100 mM in water

Safety information for PMPA(NAALADaseinhibitor)

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation
Precautionary Statement Codes	P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.