PLECONARIL

Synonym(s):3-[3,5-Dimethyl-4-[3-(3-methyl-5-isoxazolyl)propoxy]phenyl]-5-(trifluoromethyl)-1,2,4-oxadiazole;VP 63843;Win 63843

CAS NO.：153168-05-9
Empirical Formula: C18H18F3N3O3
Molecular Weight: 381.35
MDL number: MFCD00923611
SAFETY DATA SHEET (SDS)
Update Date: 2026-05-28 06:18:48

What is PLECONARIL?

Chemical properties

Off-White Solid

The Uses of PLECONARIL

Pleconaril has been used as a control or reference compound to assess the antiviral activities of the benzothiophene and other heteroaromatic derivatives against hRV-B14, hRV-A21 and hRV-A71.

The Uses of PLECONARIL

Picornavirus replication inhibitor. Antiviral.

What are the applications of Application

Pleconaril is A picornavirus replication inhibitor

General Description

Pleconaril is a drug, that has antiviral activity.

Pharmaceutical Applications

An oxadiazole active against most enteroviruses and rhinoviruses. It binds to the hydrophobic pocket of the virus capsid protein VP1, inducing conformational changes that lead to altered receptor binding and viral uncoating. Concerns over safety and efficacy have constrained development of the drug.

Biochem/physiol Actions

Pleconaril is an effective drug against enteroviral infections. It can be used to treat chronic meningoencephalitis caused by echo virus 6.This can block viral replication by blocking the viral uncoating process and viral attachment to host cell receptors.

Properties of PLECONARIL

Melting point:	61-62°
Boiling point:	481.2±55.0 °C(Predicted)
Density	1.271
storage temp.	room temp
solubility	DMSO: ≥10mg/mL (warmed)
pka	-1.33±0.10(Predicted)
form	powder
color	white to beige

Safety information for PLECONARIL

Signal word	Danger
Pictogram(s)	Skull and Crossbones Acute Toxicity GHS06
GHS Hazard Statements	H301:Acute toxicity,oral H413:Hazardous to the aquatic environment, long-term hazard
Precautionary Statement Codes	P273:Avoid release to the environment.