PLECONARIL
Synonym(s):3-[3,5-Dimethyl-4-[3-(3-methyl-5-isoxazolyl)propoxy]phenyl]-5-(trifluoromethyl)-1,2,4-oxadiazole;VP 63843;Win 63843
- CAS NO.：153168-05-9
- Empirical Formula: C18H18F3N3O3
- Molecular Weight: 381.35
- MDL number: MFCD00923611
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-28 14:58:11
What is PLECONARIL?
Chemical properties
Off-White Solid
The Uses of PLECONARIL
Pleconaril has been used as a control or reference compound to assess the antiviral activities of the benzothiophene and other heteroaromatic derivatives against hRV-B14, hRV-A21 and hRV-A71.
The Uses of PLECONARIL
Picornavirus replication inhibitor. Antiviral.
What are the applications of Application
Pleconaril is A picornavirus replication inhibitor
General Description
Pleconaril is a drug, that has antiviral activity.
Pharmaceutical Applications
An oxadiazole active against most enteroviruses and rhinoviruses. It binds to the hydrophobic pocket of the virus capsid protein VP1, inducing conformational changes that lead to altered receptor binding and viral uncoating. Concerns over safety and efficacy have constrained development of the drug.
Biochem/physiol Actions
Pleconaril is an effective drug against enteroviral infections. It can be used to treat chronic meningoencephalitis caused by echo virus 6.This can block viral replication by blocking the viral uncoating process and viral attachment to host cell receptors.
Properties of PLECONARIL
| Melting point: | 61-62° |
| Boiling point: | 481.2±55.0 °C(Predicted) |
| Density | 1.271 |
| storage temp. | room temp |
| solubility | DMSO: ≥10mg/mL (warmed) |
| pka | -1.33±0.10(Predicted) |
| form | powder |
| color | white to beige |
Safety information for PLECONARIL
| Signal word | Danger |
| Pictogram(s) |
 Skull and Crossbones Acute Toxicity GHS06 |
| GHS Hazard Statements |
H301:Acute toxicity,oral H413:Hazardous to the aquatic environment, long-term hazard |
| Precautionary Statement Codes |
P273:Avoid release to the environment. |
Computed Descriptors for PLECONARIL
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