PICROTIN
- CAS NO.：21416-53-5
- Empirical Formula: C15H18O7
- Molecular Weight: 310.3
- MDL number: MFCD00868514
- SAFETY DATA SHEET (SDS)
- Update Date: 2025-12-07 19:09:50
What is PICROTIN?
Description
Picrotin is a natural picrotoxane that antagonizes glycine receptors (GlyRs; IC50s = 57 and 117 μM for α1 and α2 homodimeric GlyRs, respectively). It also inhibits α3 homodimeric GlyRs. Picrotin is inactive in inhibiting γ-aminobutyric acid (GABA) type A and type C receptors. Picrotin occurs in the natural plant-derived poison picrotoxin , equimolar with picrotoxinin.
The Uses of PICROTIN
GABAa receptor antagonist
What are the applications of Application
Picrotin is Non-toxic component of picrotoxin
Definition
ChEBI: Picrotin is an organic heteropentacyclic compound that is picrotoxinin in which the olefinic double bond has undergone addition of water to give the corresponding tertiary alcohol. It is the less toxic component of picrotoxin, lacking GABA activity. It has a role as a plant metabolite. It is an organic heteropentacyclic compound, an epoxide, a tertiary alcohol, a gamma-lactone, a diol and a picrotoxane sesquiterpenoid. It is functionally related to a picrotoxinin.
Properties of PICROTIN
| Melting point: | 256-258°C |
| Boiling point: | 595.8±50.0 °C(Predicted) |
| alpha | D -64.7° (c = 2.31 in abs alc) |
| Density | 1.59 |
| storage temp. | 2-8°C |
| solubility | DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2)(1:9): 0.1 mg/ml |
| pka | 13.28±0.60(Predicted) |
| form | neat |
| form | Solid |
| color | White to off-white |
| EPA Substance Registry System | Picrotin (21416-53-5) |
Safety information for PICROTIN
Computed Descriptors for PICROTIN
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