PICROTIN

CAS NO.：21416-53-5
Empirical Formula: C15H18O7
Molecular Weight: 310.3
MDL number: MFCD00868514
SAFETY DATA SHEET (SDS)
Update Date: 2026-02-28 20:04:36

What is PICROTIN?

Description

Picrotin is a natural picrotoxane that antagonizes glycine receptors (GlyRs; IC₅₀s = 57 and 117 μM for α₁ and α₂ homodimeric GlyRs, respectively). It also inhibits α₃ homodimeric GlyRs. Picrotin is inactive in inhibiting γ-aminobutyric acid (GABA) type A and type C receptors. Picrotin occurs in the natural plant-derived poison picrotoxin , equimolar with picrotoxinin.

The Uses of PICROTIN

GABAa receptor antagonist

What are the applications of Application

Picrotin is Non-toxic component of picrotoxin

Definition

ChEBI: Picrotin is an organic heteropentacyclic compound that is picrotoxinin in which the olefinic double bond has undergone addition of water to give the corresponding tertiary alcohol. It is the less toxic component of picrotoxin, lacking GABA activity. It has a role as a plant metabolite. It is an organic heteropentacyclic compound, an epoxide, a tertiary alcohol, a gamma-lactone, a diol and a picrotoxane sesquiterpenoid. It is functionally related to a picrotoxinin.

Properties of PICROTIN

Melting point:	256-258°C
Boiling point:	595.8±50.0 °C(Predicted)
alpha	D -64.7° (c = 2.31 in abs alc)
Density	1.59
storage temp.	2-8°C
solubility	DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2)(1:9): 0.1 mg/ml
pka	13.28±0.60(Predicted)
form	neat
form	Solid
color	White to off-white
EPA Substance Registry System	Picrotin (21416-53-5)