Phthalimidine, 2-(2,6-dioxopiperiden-3-yl).
- CAS NO.：26581-81-7
- Empirical Formula: C13H12N2O3
- Molecular Weight: 244.25
- SAFETY DATA SHEET (SDS)
- Update Date: 2025-11-10 18:04:36
What is Phthalimidine, 2-(2,6-dioxopiperiden-3-yl).?
Description
Phthalimidine, 2-(2,6-dioxopiperiden-3-yl) is a lenalidomide analog that can be useful in PROTAC research.
General Description
White crystalline powder.
Air & Water Reactions
Insoluble in water.
Reactivity Profile
Phthalimidine, 2-(2,6-dioxopiperiden-3-yl). is an example of an amide. Amides/imides react with azo and diazo compounds to generate toxic gases. Flammable gases are formed by the reaction of organic amides/imides with strong reducing agents. Amides are very weak bases (weaker than water). Imides are less basic yet and in fact react with strong bases to form salts. That is, they can react as acids. Mixing amides with dehydrating agents such as P2O5 or SOCl2 generates the corresponding nitrile. The combustion of these compounds generates mixed oxides of nitrogen (NOx).
Health Hazard
ACUTE/CHRONIC HAZARDS: When heated to decomposition Phthalimidine, 2-(2,6-dioxopiperiden-3-yl). emits toxic fumes of nitrogen oxides.
Fire Hazard
Flash point data for Phthalimidine, 2-(2,6-dioxopiperiden-3-yl). are not available; however, Phthalimidine, 2-(2,6-dioxopiperiden-3-yl). is probably combustible.
Properties of Phthalimidine, 2-(2,6-dioxopiperiden-3-yl).
| Boiling point: | 383.99°C (rough estimate) |
| Density | 1.2650 (rough estimate) |
| refractive index | 1.5300 (estimate) |
| storage temp. | -20°C |
| solubility | DMF: 5 mg/ml,DMF:PBS (pH 7.2) (1:4): 0.2 mg/ml,DMSO: 1 mg/ml |
| pka | 10.70±0.40(Predicted) |
| form | A crystalline solid |
| color | Off-white to gray |
| EPA Substance Registry System | 2-(1-Oxo-2-isoindolinyl)glutarimide (26581-81-7) |
Safety information for Phthalimidine, 2-(2,6-dioxopiperiden-3-yl).
Computed Descriptors for Phthalimidine, 2-(2,6-dioxopiperiden-3-yl).
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![2-[2,6-DIOXO-3-(TRIFLUOROMETHYL)PIPERIDIN-3-YL]-1H-ISOINDOLE-1,3(2H)-DIONE](https://img.chemicalbook.in/StructureFile/ChemBookStructure9/GIF/CB1485860.gif)
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