Phenylacetylurea

Absorption

Almost completely absorbed.

Toxicity

Oral, mouse: LD50 = 987 mg/kg; Oral, rabbit: LD50 = 2500 mg/kg; Oral, rat: LD50 = 1600 mg/kg

Chemical properties

white to yellow powder

The Uses of Phenylacetylurea

Anticonvulsant.

Background

Phenacemide is used to control certain seizures in the treatment of epilepsy. This medicine acts on the central nervous system (CNS) to reduce the number and severity of seizures.

Indications

Used to control certain seizures in the treatment of epilepsy.

Definition

ChEBI: Phenacemide is a member of acetamides.

brand name

Phenurone (Abbott).

Pharmacokinetics

Phenacemide is a ureal anticonvulsant indicated for control of severe epilepsy, particularly mixed forms of complex partial (psychomotor or temporal lobe) seizures, refractory to other anticonvulsants. Phenacemide elevates the threshold for minimal electroshock convulsions and abolishes the tonic phase of maximal electroshock seizures. It also prevents or modifies seizures induced by pentylenetetrazol or other convulsants.

Safety Profile

Moderately toxic by ingestion and intraperitoneal routes. Experimental teratogenic effects. Used as an anticonvulsive agent. When heated to decomposition it emits toxic fumes of NOx.

Metabolism

Metabolized in the liver by hepatic microsomal enzymes, where it is inactivated by p-hydroxylation.