PHACLOFEN
Synonym(s):3-Amino-2-(4-chlorophenyl)propanephosphonic acid
- CAS NO.：114012-12-3
- Empirical Formula: C9H13ClNO3P
- Molecular Weight: 249.63
- MDL number: MFCD00069328
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-13 11:19:40
What is PHACLOFEN?
The Uses of PHACLOFEN
Phaclofen is a selective GABAB?receptor antagonist.
What are the applications of Application
Phaclofen is a selective GABAB receptor antagonist
General Description
Phaclofen is a phosphonic acid derivative of baclofen.
Biological Activity
Selective GABA B antagonist. Phosphono analog of GABA B agonist baclofen ((RS)-4-Amino-3-(4-chlorophenyl)butanoic acid ).
Biochem/physiol Actions
Phaclofen plays a vital role in identifying the physiological importance of central and peripheral bicuculline-insensitive receptors with which GABA and (?) baclofen interact. Phaclofen acts as a GABAB receptor antagonist. Phaclofen has an ability to reversibly block the late, bicuculline resistant, K+ dependent inhibitory postsynaptic potential (IPSP) logged in projection cells of the cat and rat dorsal lateral geniculate nucleus and in rat hippocampal CA1 pyramidal neurons.
Properties of PHACLOFEN
| Melting point: | 249-252 °C |
| Boiling point: | 467.1±55.0 °C(Predicted) |
| Density | 1.432±0.06 g/cm3(Predicted) |
| storage temp. | Store at RT |
| solubility | 0.1 M HCl: 13.3 mg/mL |
| form | solid |
| pka | 1.87±0.10(Predicted) |
| color | white |
Safety information for PHACLOFEN
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for PHACLOFEN
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