PHACLOFEN

Synonym(s):3-Amino-2-(4-chlorophenyl)propanephosphonic acid

CAS NO.：114012-12-3
Empirical Formula: C9H13ClNO3P
Molecular Weight: 249.63
MDL number: MFCD00069328
SAFETY DATA SHEET (SDS)
Update Date: 2026-05-28 05:23:16

What is PHACLOFEN?

The Uses of PHACLOFEN

Phaclofen is a selective GABAB?receptor antagonist.

What are the applications of Application

Phaclofen is a selective GABAB receptor antagonist

General Description

Phaclofen is a phosphonic acid derivative of baclofen.

Biological Activity

Selective GABA B antagonist. Phosphono analog of GABA B agonist baclofen ((RS)-4-Amino-3-(4-chlorophenyl)butanoic acid ).

Biochem/physiol Actions

Phaclofen plays a vital role in identifying the physiological importance of central and peripheral bicuculline-insensitive receptors with which GABA and (?) baclofen interact. Phaclofen acts as a GABAB receptor antagonist. Phaclofen has an ability to reversibly block the late, bicuculline resistant, K+ dependent inhibitory postsynaptic potential (IPSP) logged in projection cells of the cat and rat dorsal lateral geniculate nucleus and in rat hippocampal CA1 pyramidal neurons.

Properties of PHACLOFEN

Melting point:	249-252 °C
Boiling point:	467.1±55.0 °C(Predicted)
Density	1.432±0.06 g/cm3(Predicted)
storage temp.	Store at RT
solubility	0.1 M HCl: 13.3 mg/mL
form	solid
pka	1.87±0.10(Predicted)
color	white

Safety information for PHACLOFEN

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.