PD 158780
- Empirical Formula: C14H12BrN5
- Molecular Weight: 330.18
- MDL number: MFCD00942160
What is PD 158780?
The Uses of PD 158780
PD 158780 is a potent tyrosine kinase inhibitor of the epidermal growth factor receptor and has been shown to delay substantial growth of tumors in vivo tumor models.
Enzyme inhibitor
This photosensitive pyridopyrimidine (FW = 330.19 g/mol), known systematically as 4-[(3-bromophenyl)amino]-6-(methylamino)pyrido[3,4- d]pyridimine, inhibits EPGFR (epidermal growth factor receptor) proteintyrosine kinase (IC50 = 8 pM). In addition, PD 158780 inhibits heregulinstimulated autophosphorylation in SK-BR-3 (IC50 = 49 nM) and MDA-MB- 453 (IC50 = 52 nM) breast carcinomas.
Properties of PD 158780
| storage temp. | -20°C |
Safety information for PD 158780
Computed Descriptors for PD 158780
New Products
3-azanyl-3-phenyl-propanoic acid 3-AMINO-3-(2-METHYLPHENYL)PROPANOIC ACID 3-AMINO-3-M-TOLYL-PROPIONIC ACID Nitroso Irbesartan N-Nitroso Nortriptyline 1-nitro-3,5-dimethyl adamantine (NMEM) 3-(2-aminoethyl) benzene sulfonamide Nabumetone Impurity 5 2,2-dibromo-1-cyclopropyl-2-(2-fluorophenyl)ethan-1-one 4-dimethylaminopyridine 3-Bromo-2-Methyl-5-Nitropyridine 2-Chloro Isonicotinic acid methyl ester 2-(Ethoxymethylene)propanedinitrile 5-Bromo-3-Methyl-2-Pyridinecarboxylic acid 5-Chloro-pyridine-2-carboxylic acid amideRelated products of tetrahydrofuran
![N-[2-[[4-(DIETHYLAMINO)BUTYL]AMINO-6-(3,5-DIMETHOXYPHENYL)PYRIDO[2,3-D]PYRIMIDIN-7-YL]-N'-(1,1-DIMETHYLETHYL)UREA](https://img.chemicalbook.in/CAS/20140608/GIF/CB5789641.gif)
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