OPIPRAMOL
Synonym(s):4-[3-(5H-Dibenz[b,f]azepin-5-yl)-propyl]-1-piperazineethanol;NSC 169867
- CAS NO.：315-72-0
- Empirical Formula: C23H29N3O
- Molecular Weight: 363.5
- MDL number: MFCD00865455
- EINECS: 206-254-0
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-07-20 23:19:27
What is OPIPRAMOL?
Chemical properties
Crystalline Solid
Originator
Insidon,Geigy,W. Germany,1962
The Uses of OPIPRAMOL
Antidepressant; antipsychotic
What are the applications of Application
Opipramol is A tricyclic biochemical used for research purposes
Definition
ChEBI: 2-[4-[3-(11-benzo[b][1]benzazepinyl)propyl]-1-piperazinyl]ethanol is a dibenzoazepine.
Manufacturing Process
A solution of 5-(3-toluene-p-sulfonyloxypropyl)dibenzazepine (9.2g) and 1-(2hydroxyethyl)piperazine (8.6g) in anhydrous toluene (50 cc) is heated at boiling point under reflux for 4 hours.
After cooling, distilled water (75 cc) is added. The aqueous phase is decanted. The toluene solution is washed with distilled water (25 cc) and then extracted with N hydrohloric acid (40 cc). The hydrochloric acid solution is made alkaline to phenolphthalein with sodium hydroxide (d = 1.33).The base which separates is extracted with chloroform (50 cc). The chloroform solution is dried over anhydrous sodium sulfate and then evaporated to dryness. There are obtained 5-[3-(4-β-hydroxyethylpiperazino)propyl]dibenzazepine (7.95g), the dihydrochloride of which, crystallized from ethanol, melts at about 210°C.
Therapeutic Function
Antidepressant, Antipsychotic
Properties of OPIPRAMOL
| Melting point: | 100-1010C |
| Boiling point: | 494.88°C (rough estimate) |
| Density | 1.0920 (rough estimate) |
| refractive index | 1.6500 (estimate) |
| storage temp. | -20°C Freezer |
| solubility | Acetonitrile: slightly soluble; Chloroform: slightly soluble; Methanol: slightly soluble |
| pka | pKa 8(H2O,t =25,I=0.01(NaCl)) (Uncertain) |
| form | neat |
| form | Solid |
| color | Light yellow to yellow |
| BRN | 627076 |
Safety information for OPIPRAMOL
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07  Environment GHS09 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H410:Hazardous to the aquatic environment, long-term hazard |
| Precautionary Statement Codes |
P273:Avoid release to the environment. P501:Dispose of contents/container to..… |
Computed Descriptors for OPIPRAMOL
New Products
2-Amino-5-bromo- benzoic acid Dibenzoyl-L-tartaric acid Anhydrous (Resolution Reagent) 1,2,3,9-Tetrahydro-9-Methyl-4H-Carbazole-4-One Cis-Tosylate Dibenzo[b,f][1,4]thiazepin-11(10H)-one BOC Piperazine N-Methyl-2-amino-2-methylpropionamide 4-(FMOC-AMINO)-TETRAHYDROPYRAN-4-CARBOXYLIC ACID 1-Aminocyclobutanecarboxylic Acid Hydrochloride 3-Oxocyclobutanecarboxylic acid AMINO(2-BROMOPHENYL)ACETIC ACID 6-BROMOTETRAZOLO[1,5-A]PYRIDINE 4-Amino-2-chloro-6,7-dimethoxyquinazoline 2,3-Dimethoxypyridine 2,6-bis(bromomethyl)pyridine tert-Butyl 4-mercaptopiperidine-1-carboxylate 4'-(Methylmercapto)-acetophrnonone 1-Benzhydrylazetidin-3-ol-Hcl 1-(3-Chlorophenyl)piperazine hydrochloride Enzyme Breaker for Coal Bed Methane Slickwaterr Gas Well Guar Gum Enzyme Breaker Enzyme Breaker for Conventional Slickwater Fracturing Conventional Fracturing Guar Gum Enzyme Breaker Coalbed Methane Guar Gum Enzyme BreakerRelated products of tetrahydrofuran
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