OPHIOBOLIN B
- CAS NO.：5601-74-1
- Empirical Formula: C25H38O4
- Molecular Weight: 402.57
- MDL number: MFCD08061872
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-05-27 17:25:01
What is OPHIOBOLIN B?
The Uses of OPHIOBOLIN B
Ophiobolin B is a minor member of a class of phytotoxic metabolites produced by Bipolaris and other genera of plant pathogenic fungi. Ophiobolin B acts by inhibiting calmodulin action in calcium regulation.
The Uses of OPHIOBOLIN B
Calmodulin is a calcium-sensing protein that regulates a wide array of proteins involved in diverse cellular functions. Ophiobolin B is a sesterterpenoid fungal phytotoxin that binds and irreversibly antagonizes calmodulin, producing cytotoxic and antimicrobial effects. It induces apoptosis in chronic lymphocytic leukemia cells with an LC50 value of 2 nM and in different zygomycetes with MIC values ranging from 25-50 μg/ml.[Cayman Chemical]
The Uses of OPHIOBOLIN B
Ophiobolin B is a fungal phytotoxin and inhibits calmodulin (a protein involved in calcium regulation). Ophiobolin B also exhibit antibacterial and antitumor activities.
What are the applications of Application
Ophiobolin B is an inhibitor of calmodulin action in calcium regulation
Properties of OPHIOBOLIN B
| storage temp. | Store at -20°C |
| solubility | DMF: soluble; DMSO: soluble; Ethanol: soluble; Methanol: soluble |
| form | White to off-white solid. |
| color | White to off-white |
Safety information for OPHIOBOLIN B
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for OPHIOBOLIN B
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