o-Toluenesulfonyl chloride
- CAS NO.：133-59-5
- Empirical Formula: C7H7ClO2S
- Molecular Weight: 190.65
- MDL number: MFCD00024874
- EINECS: 205-113-0
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-09-12 18:48:01
What is o-Toluenesulfonyl chloride?
The Uses of o-Toluenesulfonyl chloride
o-Toluenesulfonyl chloride is used in organic synthesis and saccharin production. It is also used as pharmaceutical intermediate.
The Uses of o-Toluenesulfonyl chloride
o-Toluenesulfonyl chloride may be used in the synthesis of:
- oxazoline
- mesityl o-tolyl sulfone
- allyl o-toluenesulfonate
- 2-methyl-4′-t-butyldiphenyl sulfone
General Description
o-Toluenesulfonyl chloride can be synthesized by reacting o-thiocresol in glacial acetic acid with chlorine. It participates in the preparation of 5-chloro-3-phenyl-2,1-benzisoxazole.
Properties of o-Toluenesulfonyl chloride
| Melting point: | 10°C |
| Boiling point: | 254 °C(lit.) |
| Density | 1.320 g/mL at 25 °C(lit.) |
| refractive index | n |
| Flash point: | >230 °F |
| storage temp. | Store under inert gas |
| solubility | Acetonitrile (Slightly), Chloroform(Slightly) |
| form | clear liquid |
| color | Colorless to Light yellow |
| Water Solubility | Soluble in hot alcohol, ether and benzene. Reacts with water. |
| Sensitive | Moisture Sensitive |
| BRN | 973180 |
| CAS DataBase Reference | 133-59-5(CAS DataBase Reference) |
| EPA Substance Registry System | Benzenesulfonyl chloride, 2-methyl- (133-59-5) |
Safety information for o-Toluenesulfonyl chloride
| Signal word | Danger |
| Pictogram(s) |
 Corrosion Corrosives GHS05 |
| GHS Hazard Statements |
H314:Skin corrosion/irritation |
| Precautionary Statement Codes |
P280:Wear protective gloves/protective clothing/eye protection/face protection. P310:Immediately call a POISON CENTER or doctor/physician. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for o-Toluenesulfonyl chloride
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