NS 1738
- CAS NO.：501684-93-1
- Empirical Formula: C14H9Cl2F3N2O2
- Molecular Weight: 365.13
- MDL number: MFCD11100189
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-03-13 23:13:44
What is NS 1738?
Description
NS 1738 is a positive allosteric modulator of the α7-containing neuronal nicotinic acetylcholine receptors (nAChRs). When applied in the presence of ACh, NS 1738 increases the peak amplitude of the current flowing through α7-containing nAChRs (EC50 = 3.4 μM). NS 1738 displays no substantial activity for α4β2-, α3β3-, and α1-containing receptors. It is modestly brain-penetrant and counteracts (-)-scopolamine-induced deficit in acquisition of a water-maze learning task in rats. NS 1738 also improves performance in the rat social recognition test. NS 1738 is used to selectively evaluate the role of α7-containing nAChRs in signaling pathways.
The Uses of NS 1738
NS 1738 is a selective a7 nAchR allosteric modulator.
What are the applications of Application
NS 1738 is a selective a7 nAchR allosteric modulator
Biological Activity
Selective positive allosteric modulator of α 7 nicotinic acetylcholine receptors. Exhibits no substantial activity for α 4 β 2, α 3 β 3 and α 1-containing receptors. Displays cognitive-enhancing properties in vivo .
Storage
Store at RT
Properties of NS 1738
| Boiling point: | 344.1±42.0 °C(Predicted) |
| Density | 1.617±0.06 g/cm3(Predicted) |
| storage temp. | Store at RT |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | White crystalline solid. |
| pka | 8.08±0.13(Predicted) |
| color | Off-White to Light Grey |
Safety information for NS 1738
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H319:Serious eye damage/eye irritation |
| Precautionary Statement Codes |
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for NS 1738
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