NS1643
- CAS NO.：448895-37-2
- Empirical Formula: C15H10F6N2O3
- Molecular Weight: 380.24
- MDL number: MFCD08705418
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-03-13 23:13:44
What is NS1643?
The Uses of NS1643
NS 1643 is a human ether-a-go-go-related gene 1 potassium channel (KCNH2) activator.
What are the applications of Application
NS 1643 is an antiarrhythmic activator of hERG K+ channels
Biological Activity
Human ether-a-go-go related gene (hERG) K + channel activator (EC 50 = 10.5 μ M). Exhibits different molecular mechanisms of action at hERG1 and hERG2 channels. Displays antiarrhythmic activity in vitro .
Storage
+4°C
Properties of NS1643
| Boiling point: | 342.3±42.0 °C(Predicted) |
| Density | 1.626±0.06 g/cm3(Predicted) |
| storage temp. | Inert atmosphere,2-8°C |
| solubility | DMSO: ≥20mg/mL |
| pka | 6.84±0.13(Predicted) |
| form | solid |
| color | white to off-white |
Safety information for NS1643
| Signal word | Danger |
| Pictogram(s) |
 Skull and Crossbones Acute Toxicity GHS06 |
| GHS Hazard Statements |
H301:Acute toxicity,oral H319:Serious eye damage/eye irritation |
| Precautionary Statement Codes |
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for NS1643
New Products
Mirtazapine Impurity C/Mirtazapine Lactam Impurity Cyclopropane-1,1-dicarboxylic acid [1]Benzothieno[2,3-c]pyridine, 1,7-dichloro-8-methyl- (S)-3-Fluoro-pyrrolidine hydrochloride Cyclobutylamine 1-Bromo-2-Methoxy-3-Nitrobenzene 3-Oxocyclobutane-1-carboxylicacid (4-Bromophenyl)(3,4-dimethoxyphenyl)methanone N-Nitroso hydroxy Cetrizine EP Impurity-A Noradrenaline EP Impurity D/Noradrenaline Methyl Ether Cetirizine EP Impurity A/Cetirizine CBHP Impurity Lantanoprost rc B Clidinium Bromide Impurity 2-chloro-7-cyclopentyl-N,N-dimethylpyrrolo [2,3-d]pyrimidine-6-carbox amide 4-amino-2-fluoro-N- methylbenzamide N-(2-chloropyrimidin-4-yl)-N,2,3- trimethyl-2H- indazol 6-amine 5-Chloro-3- Methyl -1,3-2-benzoxazol-2(3H)-one 4-Bromo-2-fluoro-N-methylbenzamide N-Boc-1,4-butanediamine 4-Dimethylamino pyridine 2-Chlorotrityl Chloride 4-Bromoaniline 5-Bromo-2-chlorobenzoic acid 1,2,3,9-Tetrahydro-4(H)-carbazol-4-oneRelated products of tetrahydrofuran
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