Nicotinic acid mononucleotide
- CAS NO.：321-02-8
- Empirical Formula: C11H14NO9P
- Molecular Weight: 335.2
- MDL number: MFCD00070358
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-09-12 18:56:33
What is Nicotinic acid mononucleotide?
The Uses of Nicotinic acid mononucleotide
A nucleotide of nicotinic acid which is produced from quinolinic acid by quinolinate phosphoribosyltransferase via transfer of a phosphoribose group. It is an intermediate of nicotinic acid adenine dinucleotide (NaAD) which is then converted to NAD via amidation and in turn converted to NADPH.
What are the applications of Application
Nicotinic acid mononucleotide is can be used to study the phosphate-responsive signaling pathway in yeast
Synthesis
Nicotinic acid mononucleotide is prepared by the reaction of 2,3-dicarboxypyridine and 5-phosphoribosyl-1-pyrophosphate. The steps are as follows:
With phosphoribosyl pyrophosphate-quinolinate phosphoribosyltransferase; magnesium chloride In aq. phosphate buffer at 37℃; for 6h; pH=7.0; Enzymatic reaction.
Properties of Nicotinic acid mononucleotide
| Melting point: | >115°C (dec.) |
| storage temp. | −20°C |
| solubility | Methanol (Slightly, Heated), Water(Slightly) |
| form | Solid |
| color | White to Off-White |
| Stability: | Hygroscopic |
| InChI | InChI=1/C11H14NO9P/c13-8-7(5-20-22(17,18)19)21-10(9(8)14)12-3-1-2-6(4-12)11(15)16/h1-4,7-10,13-14H,5H2,(H2-,15,16,17,18,19)/t7-,8-,9-,10-/s3 |
Safety information for Nicotinic acid mononucleotide
Computed Descriptors for Nicotinic acid mononucleotide
| InChIKey | JOUIQRNQJGXQDC-NLNRFTKUNA-N |
| SMILES | [C@@H]1([C@H](O)[C@H](O)[C@@H](COP([O-])(=O)O)O1)[N+]1C=CC=C(C(=O)O)C=1 |&1:0,1,3,5,r| |
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