Nicaraven
- CAS NO.：79455-30-4
- Empirical Formula: C15H16N4O2
- Molecular Weight: 284.31
- MDL number: MFCD00411904
- EINECS: 1806241-263-5
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-05-28 06:19:34
What is Nicaraven?
Description
Nicaraven is an antioxidant that exhibits hydroxyl radical scavenging activity in vitro. Nicaraven (1-3 mg/kg per min, i.v.) reduces occurrence of chronic cerebral vasospasms in a dose-dependent manner in a canine model of subarachnoid hemorrhage. In a canine model of warm hepatic ischemia and reperfusion injury, nicaraven (2 mg/kg per min, i.v.) reduces liver enzyme release and inhibits lipid peroxidation and neutrophil infiltration in the liver. Nicaraven (100 mg/kg per day, i.p.) also decreases plasma levels of the inflammatory cytokines Il-6 and Tnf-α and the urinary levels of 8-oxo-2''-deoxyguanosine, a marker of DNA oxidation, in a mouse model of radiation-induced injury.
Properties of Nicaraven
| Melting point: | 156-157° |
| Boiling point: | 635.9±40.0 °C(Predicted) |
| Density | 1.213±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| solubility | DMF: 5 mg/ml; DMSO: 10 mg/ml; Ethanol: 2 mg/ml; PBS (pH 7.2): 2 mg/ml |
| form | A crystalline solid |
| pka | 12.93±0.46(Predicted) |
| color | White to off-white |
Safety information for Nicaraven
Computed Descriptors for Nicaraven
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