N-Succinimidyl-N-methylcarbamate
Synonym(s):Methyl isocyanate substitute;MIC substitute
- CAS NO.：18342-66-0
- Empirical Formula: C6H8N2O4
- Molecular Weight: 172.14
- MDL number: MFCD00800292
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-05-28 02:45:05
What is N-Succinimidyl-N-methylcarbamate?
The Uses of N-Succinimidyl-N-methylcarbamate
N-Succinimidyl N-Methylcarbamate is used as a reagent in the synthesis of Argifin, a natural product chitinase inhibitor with chemotherapeutic potential. N-Succinimidyl N-Methylcarbamate is also used as a reagent in the preparation of 5-Amino-N1-methyl-1H-imidazole-1,4-dicarboxamide (A616300); a metabolite of Temozolomide (T017775) which is an imidazotetrazine alkylating agent and antineoplastic.
Definition
ChEBI: N-succinimidyl N-methylcarbamate is a member of the class of pyrrolidinones that is N-hydroxysuccinimide in which the hydroxyl hydrogen is replaced by a methylcarbamoyl group. It has a role as an apoptosis inducer. It is a carbamate ester, a dicarboximide, a pyrrolidinone and a N-hydroxysuccinimide ester. It is functionally related to a succinimide.
Properties of N-Succinimidyl-N-methylcarbamate
| Melting point: | 148-153 °C |
| Density | 1.41±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | Dichloromethane (Slightly), DMSO (Slightly) |
| form | Solid |
| pka | 11.00±0.46(Predicted) |
| color | White to Off-White |
| Water Solubility | Slightly soluble in water. |
| Sensitive | Moisture Sensitive |
| BRN | 1531863 |
| CAS DataBase Reference | 18342-66-0(CAS DataBase Reference) |
Safety information for N-Succinimidyl-N-methylcarbamate
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for N-Succinimidyl-N-methylcarbamate
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