N-N-BUTYL-N-BUTAN-4-OL-NITROSAMINE
Synonym(s):BBN;N-Butyl-N-butan-4-ol-nitrosamine;N-Butyl-N-nitroso-4-aminobutanol;OH-BBN
- CAS NO.：3817-11-6
- Empirical Formula: C8H18N2O2
- Molecular Weight: 174.24
- MDL number: MFCD00059008
- EINECS: 625-015-5
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-03-13 15:00:32
What is N-N-BUTYL-N-BUTAN-4-OL-NITROSAMINE?
Chemical properties
red liquid
The Uses of N-N-BUTYL-N-BUTAN-4-OL-NITROSAMINE
N-Butyl-N-(4-hydroxybutyl)nitrosamine (BBN), a carcinogen, is used to induce histiologically relevant aggressive urinary bladder cancer in animal models.
Definition
ChEBI: A nitrosamine that has butyl and 4-hydroxybutyl substituents. In mice, it causes high-grade, invasive cancers in the urinary bladder, but not in any other tissues.
General Description
Dark red liquid.
Air & Water Reactions
Water soluble.
Reactivity Profile
A hydroxylated and nitrated amine. Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides.
Biochem/physiol Actions
Carcinogen used to induce urinary bladder cancer in animal models. The result of exposure is histologically comparable to human urinary bladder tumorigenesis. Used in chemopreventative studies.
Properties of N-N-BUTYL-N-BUTAN-4-OL-NITROSAMINE
| Boiling point: | 167 °C / 5mmHg |
| Density | 1.01 |
| refractive index | 1.4700-1.4740 |
| Flash point: | 147 °C |
| storage temp. | 2-8°C |
| form | clear liquid |
| pka | 15.03±0.10(Predicted) |
| color | Light yellow to Amber to Dark green |
| Stability: | Stability |
| EPA Substance Registry System | 4-(Butylnitrosoamino)butanol (3817-11-6) |
Safety information for N-N-BUTYL-N-BUTAN-4-OL-NITROSAMINE
| Signal word | Danger |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07  Health Hazard GHS08 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H350:Carcinogenicity |
| Precautionary Statement Codes |
P201:Obtain special instructions before use. P202:Do not handle until all safety precautions have been read and understood. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P308+P313:IF exposed or concerned: Get medical advice/attention. |
Computed Descriptors for N-N-BUTYL-N-BUTAN-4-OL-NITROSAMINE
New Products
Cyclopropane-1,1-dicarboxylic acid Cefuroxime EP Impurity-A N-Nitroso hydroxy Cetrizine EP Impurity-A Noradrenaline EP Impurity D/Noradrenaline Methyl Ether Cetirizine EP Impurity A/Cetirizine CBHP Impurity Lantanoprost rc B Clidinium Bromide Impurity tert-Butyl (2S)-[1-amino-3-(4-iodophenyl)-1-oxopropan-2-yl]carbamate 4-amino-2-fluoro-N- methylbenzamide 5-Chloro-3- Methyl -1,3-2-benzoxazol-2(3H)-one N-(2-chloropyrimidin-4-yl)-N,2,3- trimethyl-2H- indazol 6-amine N-Boc-1,4-butanediamine 4-Bromo-2-fluoro-N-methylbenzamide valeronitrile 3-chlorobenzyl cyanide 3,4 Dimethoxy Benzylcyanide 3,4 Diethoxy Benzylcyanide 2-Chloro Benzylcyanide 3-Hydroxypropionitrile 5-azidovalericacid 6,6'-bis(difluoromethoxy)-2,2'-bis((3,4-dimethoxypyridin-2-yl)methylsulfinyl)-1H,1'H-5,5'-bibenzo[d]imidazole (1-((2'-(2-((1-((2'-(2H-tetrazol-5-yl)biphenyl-4-yl)methyl)-2-butyl-4-chloro-1H-imidazol-5-yl)methyl)-2H-tetrazol-5-yl)biphenyl-4-yl)methyl)-2-butyl-4-chloro-1H-imidazol-5-yl)methanol (1-((2'-(1-((1-((2'-(2H-tetrazol-5-yl)biphenyl-4-yl)methyl)-2-butyl-4-chloro-1H-imidazol-5-yl)methyl)-1H-tetrazol-5-yl)biphenyl-4-yl)methyl)-2-butyl-4-chloro-1H-imidazol-5-yl)methanol (4-Methoxyphenyl) hydrazine HydrochlorideRelated products of tetrahydrofuran
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