N-N-BUTYL-N-BUTAN-4-OL-NITROSAMINE

Synonym(s):BBN;N-Butyl-N-butan-4-ol-nitrosamine;N-Butyl-N-nitroso-4-aminobutanol;OH-BBN

CAS NO.：3817-11-6
Empirical Formula: C8H18N2O2
Molecular Weight: 174.24
MDL number: MFCD00059008
EINECS: 625-015-5
SAFETY DATA SHEET (SDS)
Update Date: 2025-12-05 14:33:18

N-N-BUTYL-N-BUTAN-4-OL-NITROSAMINE Structural

What is N-N-BUTYL-N-BUTAN-4-OL-NITROSAMINE?

Chemical properties

red liquid

The Uses of N-N-BUTYL-N-BUTAN-4-OL-NITROSAMINE

N-Butyl-N-(4-hydroxybutyl)nitrosamine (BBN), a carcinogen, is used to induce histiologically relevant aggressive urinary bladder cancer in animal models.

Definition

ChEBI: A nitrosamine that has butyl and 4-hydroxybutyl substituents. In mice, it causes high-grade, invasive cancers in the urinary bladder, but not in any other tissues.

General Description

Dark red liquid.

Air & Water Reactions

Water soluble.

Reactivity Profile

A hydroxylated and nitrated amine. Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides.

Biochem/physiol Actions

Carcinogen used to induce urinary bladder cancer in animal models. The result of exposure is histologically comparable to human urinary bladder tumorigenesis. Used in chemopreventative studies.

Properties of N-N-BUTYL-N-BUTAN-4-OL-NITROSAMINE

Boiling point:	167 °C / 5mmHg
Density	1.01
refractive index	1.4700-1.4740
Flash point:	147 °C
storage temp.	2-8°C
form	clear liquid
pka	15.03±0.10(Predicted)
color	Light yellow to Amber to Dark green
Stability:	Stability
EPA Substance Registry System	4-(Butylnitrosoamino)butanol (3817-11-6)

Safety information for N-N-BUTYL-N-BUTAN-4-OL-NITROSAMINE

Signal word	Danger
Pictogram(s)	Exclamation Mark Irritant GHS07 Health Hazard GHS08
GHS Hazard Statements	H302:Acute toxicity,oral H350:Carcinogenicity
Precautionary Statement Codes	P201:Obtain special instructions before use. P202:Do not handle until all safety precautions have been read and understood. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P308+P313:IF exposed or concerned: Get medical advice/attention.