N-Methoxysuccinyl-Ala-Ala-Pro-Val p-nitroanilide
Synonym(s):Elastase Substrate I, Colorimetric - CAS 70967-90-7 - Calbiochem;Methoxysuccinyl-Ala-Ala-Pro-Val-p-nitroanilide - CAS 70967-90-7 - Calbiochem;N-(Methoxysuccinyl)-L -alanyl-L -alanyl-L -prolyl-L -valine 4-nitroanilide;N-(Methoxysuccinyl)-Ala-Ala-Pro-Val 4-nitroanilide
- CAS NO.：70967-90-7
- Empirical Formula: C27H38N6O9
- Molecular Weight: 590.63
- MDL number: MFCD00077137
- EINECS: 232-670-7
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-09-12 18:50:04
What is N-Methoxysuccinyl-Ala-Ala-Pro-Val p-nitroanilide?
Description
Proteinase 3 (PR3, myeloblastin) is a polymorphonuclear leukocyte serine proteinase that degrades matrix proteins including fibronectin, laminin, vitronectin, and collagen type IV to generate antimicrobial peptides. Neutrophil elastase is a serine proteinase that is secreted by neutrophils during inflammation to destroy pathogens. Evaluating these enzymes is helpful to understanding inflammatory autoimmune processes. MeOSuc-AAPV-pNA is a highly sensitive peptide substrate that is hydrolyzed by both human and mouse neutrophil elastase and PR3, but not cathepsin G or chymotrypsin. Enzyme activity can be quantified by colorimetric detection of free p-nitroanilide at 405 nm.
The Uses of N-Methoxysuccinyl-Ala-Ala-Pro-Val p-nitroanilide
N-Methoxysuccinyl-Ala-Ala-Pro-Val p-Nitroanilide is a highly sensitive peptide substrate that is hydrolyzed by both human and mouse neutrophil elastase and PR3 but not cathespin.
What are the applications of Application
MeOSuc-AAPV-pNA, Chromogenic Substrate is a sensitive PR3 and neutrophil elastase chromogenic substrate
Properties of N-Methoxysuccinyl-Ala-Ala-Pro-Val p-nitroanilide
| Melting point: | 203-205°C |
| Boiling point: | 958.4±65.0 °C(Predicted) |
| Density | 1.297±0.06 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | DMF: 25 mg/mL, clear, light yellow |
| form | Off-white solid |
| pka | 13.29±0.20(Predicted) |
| color | White to Off-White |
| BRN | 6266359 |
Safety information for N-Methoxysuccinyl-Ala-Ala-Pro-Val p-nitroanilide
Computed Descriptors for N-Methoxysuccinyl-Ala-Ala-Pro-Val p-nitroanilide
New Products
Cyclobutanone (R)-(-)-2-Amino-1-propanol Fmoc-OSu 5-bromo-4-fluoro-2-nitrobenzaldehyde 2-Amino-2-(4-methylphenyl)acetic acid 1-(2-Chloroethyl)pyrrolidine Hydrochloride 2,4-Dihydroxybenzaldehyde Obidoxime hydrochloride API Pyrrolo[1,2-a]pyrimidine-6-carboxylic acid, 4,6,7,8-tetrahydro-4-oxo-, sodium salt (1:1), (6S) Dipropyl disulfide N-Vinylformamide 4 pentyn 1 ol Methacrylate-PEG-Methacrylate, Mn:35000 2,4-Dihydroxyacetophenone 2-Chloro 5-Fluoro Pyridine Vasicinone 2-Chloroisonicotinic Acid Tween 80 or Polysorbate 80 2-Butyn-1-oL N-(4-fluoro-2-methoxy-5-nitrophenyl)-4-(1-methyl-1H-indol-3-yl)pyrimidin-2-amine Pirtobrutinib intd. 2-Pentyn-1-oL 4-Nitrobenzotrifluoride N-(4-Cyano-3-(trifluoromethyl)phenyl)-2-methyloxirane-2-carboxamideRelated products of tetrahydrofuran
You may like
-
N-Methoxysuccinyl-Ala-Ala-Pro-Val p-nitroanilide 98% (HPLC) CAS 70967-90-7View Details
70967-90-7 -
Elastase Substrate I, Colorimetric CAS 70967-90-7View Details
70967-90-7 -
N-Methoxysuccinyl-Ala-Ala-Pro-Val p-nitroanilide CAS 70967-90-7View Details
70967-90-7 -
Methoxysuccinyl-Ala-Ala-Pro-Val-p-nitroanilide CAS 70967-90-7View Details
70967-90-7 -
545445-44-1 3-Morpholino-1-(4-(2-oxopiperidin-1-yl) phenyl)-5,6-dihyropyridin-2-(1H)-one 98%View Details
545445-44-1 -
6629-04-5 98%View Details
6629-04-5 -
4-(4-Αminophenyl)-3-Morpholinone 98%View Details
438056-69-0 -
1-(4-Aminophenyl)-3-morpholino-5,6-dihydropyridin-2(1H)-one 1267610-26-3 98%View Details
1267610-26-3