N-Boc-2-piperidone

Chemical properties

Off-White Low Melting Solid

The Uses of N-Boc-2-piperidone

Intermediate in the preparation of various biological inhibitors.

What are the applications of Application

1-N-Boc-2-piperidone is a useful boc protected biochemical for proteomics research

Definition

ChEBI:N-Boc-2-piperidone-protected by t-Boc. It is also known as 1-N-Boc-2-piperidone,1-N-Boc-2-piperidone, or 1-(tert-Butoxycarbonyl)-2-piperidone. 

Preparation

4-Benzensulfonylmethyl-4-hydroxy-piperidine TFA (B-1) Diisopropylethylamine (28.3 mL, 162.75 mmol) and di-t-butyl dicarbonate (28.4 g, 130.02 mmol) were added in sequence to a mixture of piperidone hydrate hydrochloride (12) (10.0 g, 65.1 mmol) in methanol (50 mL).  The mixture was stirred at room temperature for 20 hours. After that, removed the solvent  and the remaining was separated with ether and 1 M KHSO₄ solution.  The organic layer was washed with brine and saturated NaHCO₃.  Finally, N-Boc-2-piperidone was obtained after purification.