N-(4-chlorophenyl)-N-(1-isopropyl-4-piperidyl)phenylacetamide monohydrochloride

CAS NO.：58934-46-6
Empirical Formula: C22H28Cl2N2O
Molecular Weight: 407.37652
EINECS: 261-504-6
SAFETY DATA SHEET (SDS)
Update Date: 2026-01-13 11:19:26

What is N-(4-chlorophenyl)-N-(1-isopropyl-4-piperidyl)phenylacetamide monohydrochloride?

Description

Lorcainide hydrochloride (58934-46-6) is a voltage-gated Na+?channel blocker.1?Protects murine cultured cortical neurons from injury induced by oxygen-glucose deprivation.2?Acts at the ouabain binding site of guinea pig cardiac Na+/K+?ATPase and inhibits the enzyme (IC50?= 34 μM).3

The Uses of N-(4-chlorophenyl)-N-(1-isopropyl-4-piperidyl)phenylacetamide monohydrochloride

Cardiac depressant (anti-arrhythmic).

What are the applications of Application

Lorcainide HCl is an inhibitor of sodium voltage-gated channels

References

1) Sheldon?et al.?(1989),?Antiarrhythmic drugs and the cardiac sodium channel: current models; Clin. Chem.,?35?748 2) Lynch?et al.?(1995),?Sodium channel clockers reduce oxygen-glucose deprivation-induced cortical neuronal injury when combined with glutamate receptor antagonists; J. Pharmacol. Exp. Ther.,?273?554 3) Almotrefi?et al. (1999),?Class I antiarrhythmic drug effects on ouabain binding to guinea pig cardiac Na+ -K+ ATPase; Can. J. Physiol. Pharmacol.,?77?866

Properties of N-(4-chlorophenyl)-N-(1-isopropyl-4-piperidyl)phenylacetamide monohydrochloride

Melting point:	263°
storage temp.	-20°C
solubility	Soluble in DMSO (up to 20 mg/ml), in Water (up to 20 mg/ml), or in Ethanol (up to 20 mg/ml).
form	White solid.
color	Powder
Stability:	Stable for 1 year from date of purchase as supplied. Solutions in DMSO, distilled water or ethanol may be stored at -20°C for up to 1 month

Safety information for N-(4-chlorophenyl)-N-(1-isopropyl-4-piperidyl)phenylacetamide monohydrochloride

Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral
Precautionary Statement Codes	P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth.

Computed Descriptors for N-(4-chlorophenyl)-N-(1-isopropyl-4-piperidyl)phenylacetamide monohydrochloride

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