N,N-Dimethylpiperidin-4-amine

CAS NO.：50533-97-6
Empirical Formula: C7H16N2
Molecular Weight: 128.22
MDL number: MFCD00023144
EINECS: 256-617-2
SAFETY DATA SHEET (SDS)
Update Date: 2026-01-13 11:12:54

What is N,N-Dimethylpiperidin-4-amine?

The Uses of N,N-Dimethylpiperidin-4-amine

4-(Dimethylamino)piperidine is having molecular features associated with polyamine modulation of N-methyl-D-aspartate receptors. It is utilized as a mechanism for reducing the effects of alcohol dependence.

Synthesis

1-(tert-Butoxycarbonyl)-4-piperidone (998 mg, 4.75 mmol) in methanol (15 mL) was treated with dimethylamine hydrochloride (800 mg, 9.8 mmol) and sodium cyanoborohydride (270 mg, 4.3 mmol) at rt. After 4 days, concentrated HCl (10 mL) was added and the reaction was reduced in vacuo. The resulting residue was dissolved in H2O (30 mL) and treated with 2M NaOH solution to achieve a pH of 10. The aqueous solution was extracted with methylene chloride (3×20 mL) and the combined organics were dried over Na2SO4 and removed in vacuo. The resulting product is N,N-Dimethylpiperidin-4-amine (169 mg).

Storage

Incompatible with air, water, oxidizing agents and heat.

Properties of N,N-Dimethylpiperidin-4-amine

Boiling point:	187°C
Density	1.09g/ml
Flash point:	187°C
refractive index	1.4760
storage temp.	under inert gas (nitrogen or Argon) at 2–8 °C
pka	10.10±0.10(Predicted)
color	Clear, colourless
BRN	1190
CAS DataBase Reference	50533-97-6(CAS DataBase Reference)

Safety information for N,N-Dimethylpiperidin-4-amine

Signal word	Danger
Pictogram(s)	Corrosion Corrosives GHS05
GHS Hazard Statements	H314:Skin corrosion/irritation H318:Serious eye damage/eye irritation
Precautionary Statement Codes	P301+P330+P331:IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up.