N6-Trifluoroacetyl-L-lysine N-Carboxyanhydride
- CAS NO.：42267-27-6
- Empirical Formula: C9H11F3N2O4
- Molecular Weight: 268.19
- MDL number: MFCD11046652
- EINECS: 610-008-1
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-06-19 07:28:27
What is N6-Trifluoroacetyl-L-lysine N-Carboxyanhydride?
Description
N6-Trifluoroacetyl-L-lysine N-Carboxyanhydride is a N6-trifluoroacetylated lysine derivative that is used in the synthesis of peptides. It is a racemic mixture of L and D forms, which is hydrolyzed to form L-glutamic acid, NH4Cl, and CO2. N6-Trifluoroacetyl-L-lysine N-Carboxyanhydride has been shown to be useful in the formation of bonds between amino acids, such as lysine and dipeptides. The compound is also used for the protection of lysine against oxidation during peptide synthesis.
Chemical properties
White to Off-White Solid
The Uses of N6-Trifluoroacetyl-L-lysine N-Carboxyanhydride
L-Lys(Tfa)-NCA can be used in the synthesis of new arborescent architectures of poly(L-lysine), called lysine dendrigraft (DGL) polymers.
The Uses of N6-Trifluoroacetyl-L-lysine N-Carboxyanhydride
Used in the synthesis of new arborescent architectures of poly(L-lysine), called lysine dendrigraft (DGL) polymers. ?DGL polymers were prepd. through a multiple-generation scheme (up to generation 5) in a weakly acidic aq. medium by polycondensing N.vepsiln.-trifluoroacetyl-L-lysine-N-carboxyanhydride (Lys(Tfa)-NCA) onto the previous generation G(n-1) of DGL, which was used as a macroinitiator.
Properties of N6-Trifluoroacetyl-L-lysine N-Carboxyanhydride
| Melting point: | 92-93℃ (DEC.) |
| Density | 1.377 |
| storage temp. | Inert atmosphere,Store in freezer, under -20°C |
| solubility | DMSO (Slightly), Ethyl Acetate (Slightly) |
| form | Solid |
| pka | 9.27±0.40(Predicted) |
| color | White to Off-White |
| InChI | InChI=1S/C9H11F3N2O4/c10-9(11,12)7(16)13-4-2-1-3-5-6(15)18-8(17)14-5/h5H,1-4H2,(H,13,16)(H,14,17)/t5-/m0/s1 |
Safety information for N6-Trifluoroacetyl-L-lysine N-Carboxyanhydride
Computed Descriptors for N6-Trifluoroacetyl-L-lysine N-Carboxyanhydride
| InChIKey | KWNIHCJDDYRQFW-YFKPBYRVSA-N |
| SMILES | C(NCCCC[C@H]1C(=O)OC(=O)N1)(=O)C(F)(F)F |
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