N-(2-Aminoethyl)piperidine

Synonym(s):2-Piperidinoethylamine

CAS NO.：27578-60-5
Empirical Formula: C7H16N2
Molecular Weight: 128.22
MDL number: MFCD00006516
EINECS: 248-540-8
SAFETY DATA SHEET (SDS)
Update Date: 2025-09-25 17:15:13

What is N-(2-Aminoethyl)piperidine?

Chemical properties

CLEAR COLOURLESS TO YELLOW LIQUID

The Uses of N-(2-Aminoethyl)piperidine

1-(2-Aminoethyl)piperidine is used in modification of vinylbenzyl chloride/divinylbenzene gel copolymer bead and in the synthesis of linkage isomers trans-bis[1-(2-aminoethyl)piperidine]dinitronickel and trans-bis[1-(2-aminoethyl)-piperidine]dinitritonickel. It is also used as a reactant for synthesis of: analogs of anticancer agents, inhibitor of botulinum neurotoxin serotype A light chain, P. falciparum malaria, and Ebola filovirus, cannabinoid CB1 receptor antagonists, small molecules that restore E-cadherin expression and reduce invasion in colorectal carcinoma cells, potent and selective 5-HT6 antagonists and N-mustards as anticancer agents. 1-(2-Aminoethyl)piperidine on [1+1] condensation reaction with 3-methoxy salicylaldehyde yields tridentate Schiff base ligand.

General Description

1-(2-Aminoethyl)piperidine on [1+1] condensation reaction with 3-methoxy salicylaldehyde yields tridentate Schiff base ligand.

Properties of N-(2-Aminoethyl)piperidine

Melting point:	67-70 °C(Solv: ligroine (8032-32-4); dichloromethane (75-09-2))
Boiling point:	186 °C(lit.)
Density	0.899 g/mL at 25 °C(lit.)
refractive index	n20/D 1.473(lit.)
Flash point:	136 °F
storage temp.	under inert gas (nitrogen or Argon) at 2–8 °C
form	Liquid
pka	pK1: 6.38;pK2: 9.89 (30°C)
color	Clear colorless to yellow
Water Solubility	Partly miscible in water.
Sensitive	Air Sensitive
BRN	103469
CAS DataBase Reference	27578-60-5(CAS DataBase Reference)
NIST Chemistry Reference	1-Piperidineethanamine(27578-60-5)

Safety information for N-(2-Aminoethyl)piperidine

Signal word	Danger
Pictogram(s)	Flame Flammables GHS02 Corrosion Corrosives GHS05
GHS Hazard Statements	H226:Flammable liquids H314:Skin corrosion/irritation
Precautionary Statement Codes	P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P233:Keep container tightly closed. P240:Ground/bond container and receiving equipment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.