N-(2-(4'-cyanobiphenyl-4-yl)propyl)propane-2-sulfonaMide
- CAS NO.：211311-95-4
- Empirical Formula: C19H22N2O2S
- Molecular Weight: 342.46
- MDL number: MFCD07364003
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-04-22 18:57:36
What is N-(2-(4'-cyanobiphenyl-4-yl)propyl)propane-2-sulfonaMide?
Description
LY404187 is a benzothiadiazide positive allosteric modulator of AMPA receptors. It increases glutamate-induced activation of GluR1i, -2i, -2o, -3i, and -4i subunit-containing AMPA receptors with EC50 values of 5.65, 0.15, 1.44, 1.66, and 0.21 μM, respectively, in a calcium influx assay. LY404187 is selective for these AMPA receptors over GluR6 subunit-containing kainate receptors at 10 μM. LY404187 increases currents induced by glutamate and AMPA in rat prefrontal cortex pyramidal neurons (EC50s = 1.3 and 1.2 μM, respectively) but not in AMPA-stimulated primary rat embryonic hippocampal or primary cerebellar Purkinje neurons. LY404187 prevents decreases in the number of dopaminergic neurons in the substantia nigra induced by MPTP and 6-OHDA in mouse and rat, respectively, models of Parkinson’s disease when administered at a dose of 0.5 mg/kg per day.
The Uses of N-(2-(4'-cyanobiphenyl-4-yl)propyl)propane-2-sulfonaMide
LY 404187 is a novel positive allosteric modulator of AMPA receptors.
Storage
Store at +4°C
Properties of N-(2-(4'-cyanobiphenyl-4-yl)propyl)propane-2-sulfonaMide
| Boiling point: | 519.0±60.0 °C(Predicted) |
| Density | 1.19±0.1 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | DMF: 15mg/mL; DMSO: 15mg/mL; DMSO:PBS (pH 7.2) (1:4): 0.2mg/mL; Ethanol: 3mg/mL |
| form | A solid |
| pka | 11.24±0.40(Predicted) |
| color | White to off-white |
Safety information for N-(2-(4'-cyanobiphenyl-4-yl)propyl)propane-2-sulfonaMide
Computed Descriptors for N-(2-(4'-cyanobiphenyl-4-yl)propyl)propane-2-sulfonaMide
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