BMS-986205
- CAS NO.：1923833-60-6
- Empirical Formula: C24H24ClFN2O
- Molecular Weight: 410.91
- MDL number: MFCD31619233
- Update Date: 2026-03-13 15:00:32
What is BMS-986205?
Description
BMS-986205, also known as Linrodostat, ONO-7701 and F001287, a potent and selective, orally active IDO1 inhibitor with potential immunomodulating and antineoplastic activities.
Biological Activity
Linrodostat (BMS-986205, ONO-7701) is an irreversible inhibitor of IDO1 with an IC50 of 1.7 nM. It inhibits kynurenine production with IC50 values of 1.7, 1.1 and > 2000 in human HeLa, HEK293 expressing human IDO-1 and tryptophan-2, 3-dioxygenase cell-based assays.
The Uses of BMS-986205
BMS-986205 is a compound being studied for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders.
Properties of BMS-986205
| Boiling point: | 606.8±45.0 °C(Predicted) |
| Density | 1?+-.0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMSO:42.0(Max Conc. mg/mL);73.75(Max Conc. mM) Ethanol:100.0(Max Conc. mg/mL);175.59(Max Conc. mM) |
| form | Solid |
| pka | 13.80±0.70(Predicted) |
| color | White to off-white |
Safety information for BMS-986205
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for BMS-986205
New Products
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