MONOSIALOGANGLIOSIDE GM3
- CAS NO.：54827-14-4
- Empirical Formula: C64H118N2O21.H3N
- Molecular Weight: 1268.66
- MDL number: MFCD00131139
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-13 11:20:29
What is MONOSIALOGANGLIOSIDE GM3?
The Uses of MONOSIALOGANGLIOSIDE GM3
Monosialoganglioside GM3 can have anti-tumor effects by regulating cell apoptosis, angiogenesis. Monosialoganglioside GM3 can also regulate peripheral insulin receptor signaling and increases in GM3 in adipose tissue of obese humans may contribute to insulin resistance.
The Uses of MONOSIALOGANGLIOSIDE GM3
Monosialoganglioside GM3 from canine blood has been used as a reference standard in high-performance thin-layer chromatography (HPTLC) to analyze ganglioside signatures of prostate cancer (CaP) cells. It has also been used to determine ganglioside-binding profiles of methylotrophic yeast (Pichia pastoris) secreted cholera toxin B subunit (PpCTB) by enzyme-linked immunosorbent assay (ELISA).
What are the applications of Application
Ganglioside GM3 sodium salt is the primary extraneuronal ganglioside
General Description
Gangliosides are major constituents of neuronal cell membranes and endoplasmic reticulum. They contain a sialated polysaccharide chain linked to ceramide through a β-glycosidic linkage. For classification of gangliosides see Svennerholm, L., et al. (eds.), Structure and Function of Gangliosides, New York, Plenum, 1980.
Biochem/physiol Actions
Monosialoganglioside GM3 has a potential role in cancer development and progression. Increased expression of GM3 has been observed in various types of cancer. Hence, it is used as a tumor-associated carbohydrate antigen during cancer vaccine development.
Properties of MONOSIALOGANGLIOSIDE GM3
| storage temp. | −20°C |
| solubility | chloroform/methanol/water (9.5:9.5:1): 20mg/mLclear, colorless to light yellow |
| form | lyophilized powder |
| color | White |
Safety information for MONOSIALOGANGLIOSIDE GM3
Computed Descriptors for MONOSIALOGANGLIOSIDE GM3
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