Methyl 1,2-dihydro-2-oxopyridine-4-carboxylate
- CAS NO.：89937-77-9
- Empirical Formula: C7H7NO3
- Molecular Weight: 153.14
- MDL number: MFCD09258780
- SAFETY DATA SHEET (SDS)
- Update Date: 2025-07-24 18:12:00
What is Methyl 1,2-dihydro-2-oxopyridine-4-carboxylate?
The Uses of Methyl 1,2-dihydro-2-oxopyridine-4-carboxylate
Methyl 1,2-dihydro-2-oxopyridine-4-carboxylate is an ester derivative, mainly used as a pharmaceutical intermediate.
Synthesis
The synthesis method of Methyl 1,2-dihydro-2-oxopyridine-4-carboxylate is as follows: Dissolve 10 g (0.066 mol) of m-nitrobenzaldehyde and 11 g (0.067 mol) of ethyl chloroacetate in 60 ml of benzene, and add 1 ml of piperidine. 1 ml of glacial acetic acid, heated in a water bath, and the water generated in the reaction was continuously removed with a Dean-start water separator. After refluxing for 3h, the benzene was evaporated, 20ml of ether was added to the residue, frozen, crystallized, suction filtered, and dried to give 16.2g of methyl 2-hydroxypyridine-4-carboxylate, yield 82%, mp 92 -96°C.
Properties of Methyl 1,2-dihydro-2-oxopyridine-4-carboxylate
| Melting point: | 211-212 °C |
| Boiling point: | 342.4±42.0 °C(Predicted) |
| Density | 1.263±0.06 g/cm3(Predicted) |
| storage temp. | Inert atmosphere,Room Temperature |
| pka | 11.02±0.10(Predicted) |
| color | White to off-white |
Safety information for Methyl 1,2-dihydro-2-oxopyridine-4-carboxylate
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for Methyl 1,2-dihydro-2-oxopyridine-4-carboxylate
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