Methanone, (3,4-dihydro-2(1H)-isoquinolinyl)[2-[(4-methoxyphenyl)amino]-4-thiazolyl]-

CAS NO.：736945-96-3
Empirical Formula: C20H19N3O2S
Molecular Weight: 365.45
Update Date: 2025-08-06 15:14:14

What is Methanone, (3,4-dihydro-2(1H)-isoquinolinyl)[2-[(4-methoxyphenyl)amino]-4-thiazolyl]-?

Description

GSK417651A (736945-96-3) is a TRPC blocker. In whole-cell patch-clamp experiments in HEK293 cells transfected with recombinant human TRPC3 or TRPC6, GSK417651A blocked both TRPC3 and TRPC6 current with IC50 of ~0.04 μM.1?Combined pharmacological blockade of TRPC3 and TRPC6 inhibits cardiac hypertrophy.2 Cell permeable

The Uses of Methanone, (3,4-dihydro-2(1H)-isoquinolinyl)[2-[(4-methoxyphenyl)amino]-4-thiazolyl]-

GSK417651A is an inhibitor of transient receptor channels 3 & 6.

References

1) Xu et al. (2013), Characterization of small molecule TRPC3 and TRPC6 agonists and antagonists; Biophys. J., 104 Supp 1 454a 2) Seo et al. (2014) Combined TRPC3 and TRPC6 blockade by selective small-molecule or genetic deletion inhibits pathological cardiac hypertrophy; Proc. Natl. Acad. Sci. USA, 111 1551

Properties of Methanone, (3,4-dihydro-2(1H)-isoquinolinyl)[2-[(4-methoxyphenyl)amino]-4-thiazolyl]-

Boiling point:	579.8±60.0 °C(Predicted)
Density	1.318±0.06 g/cm3(Predicted)
storage temp.	RT (des.)
solubility	Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 15 mg/ml with warming).
pka	2.24±0.10(Predicted)
form	solid
color	Yellow
Stability:	Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.

Safety information for Methanone, (3,4-dihydro-2(1H)-isoquinolinyl)[2-[(4-methoxyphenyl)amino]-4-thiazolyl]-

Computed Descriptors for Methanone, (3,4-dihydro-2(1H)-isoquinolinyl)[2-[(4-methoxyphenyl)amino]-4-thiazolyl]-

New Products

9-Mesityl-10-methylacridinium perchlorate Sulfapyridine Fmoc-OSu (R)-(-)-2-Amino-1-propanol Cyclobutanone 5-bromo-4-fluoro-2-nitrobenzaldehyde Phenethyl cinnamate Obidoxime hydrochloride API Pyrrolo[1,2-a]pyrimidine-6-carboxylic acid, 4,6,7,8-tetrahydro-4-oxo-, sodium salt (1:1), (6S) Dipropyl disulfide N-Vinylformamide 4 pentyn 1 ol Methacrylate-PEG-Methacrylate, Mn:35000 2,4-Dihydroxyacetophenone 2-Chloro 5-Fluoro Pyridine Vasicinone 2-Chloroisonicotinic Acid Tween 80 or Polysorbate 80 Carbozantinib intermediate(n-1) N-(4-fluoro-2-methoxy-5-nitrophenyl)-4-(1-methyl-1H-indol-3-yl)pyrimidin-2-amine Pirtobrutinib intd. N-(4-Cyano-3-(trifluoromethyl)phenyl)-2-methyloxirane-2-carboxamide 2-Pentyn-1-oL 4-Nitrobenzotrifluoride

Related products of tetrahydrofuran

Nitrendipine

SKF 96365 HYDROCHLORIDE

POLYGODIAL

4'-CHLORO-3-METHOXYCINNAMANILIDE