POLYGODIAL

Synonym(s):(1R,4aS,8aS)-1,4,4a,5,6,7,8,8a-Octahydro-5,5,8a-trimethyl-1,2-naphthalenedicarboxaldehyde

CAS NO.：6754-20-7
Empirical Formula: C15H22O2
Molecular Weight: 234.33
MDL number: MFCD00238664
SAFETY DATA SHEET (SDS)
Update Date: 2026-05-12 18:45:01

What is POLYGODIAL?

Description

Polygodial (6754-20-7) is a TRPA1 activator (EC50=400 nM).1?A naturally occurring drimane sesquiterpene dialdehyde found in a variety of plant species including water pepper (Polygonum hydropiper). Polygodial has been used in folk medicine for a variety of indications. Displays analgesic activity via desensitization of sensory neurons.2

The Uses of POLYGODIAL

Polygodial is a naturally occurring antifungal and antinociceptive.

What are the applications of Application

Polygodial is a naturally occurring antifungal and antinociceptive

Definition

ChEBI: Polygodial is an aldehyde.

Biochem/physiol Actions

Polygodial is a selective activator of Transient Receptor Potential Anykrin 1 (TRPA1) channels. Initially painful, polygodial acts as an analgesic by desensitizing sensory neuron. Polygodial also has broad antifungal properties, and is cytotoxic against bacteria and algae.

Storage

Store at -20°C

References

1) Escalera et al. (2008), TRPA1 mediates the noxious effects of natural sesquiterpene deterrents; J. Biol. Chem., 283 24136 2) Andre et al. (2004), Evidence for the involvement of vanilloid receptor in the antinociception produced by the dialdehydes unsaturated sesquiterpenes polygodial and drimanial in rats; Neuropharmacology, 46 590

Properties of POLYGODIAL

Melting point:	57° (Barnes, Loder)
Boiling point:	330.7±35.0 °C(Predicted)
alpha	D24 -131° (c = 0.96 in ethanol)
Density	1.084±0.06 g/cm3(Predicted)
RTECS	QJ2850000
storage temp.	-20°C
solubility	DMSO: soluble20mg/mL, clear
form	powder
color	white to beige
Stability:	Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.