POLYGODIAL
Synonym(s):(1R,4aS,8aS)-1,4,4a,5,6,7,8,8a-Octahydro-5,5,8a-trimethyl-1,2-naphthalenedicarboxaldehyde
- CAS NO.：6754-20-7
- Empirical Formula: C15H22O2
- Molecular Weight: 234.33
- MDL number: MFCD00238664
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-04-21 10:31:43
What is POLYGODIAL?
Description
Polygodial (6754-20-7) is a TRPA1 activator (EC50=400 nM).1?A naturally occurring drimane sesquiterpene dialdehyde found in a variety of plant species including water pepper (Polygonum hydropiper). Polygodial has been used in folk medicine for a variety of indications. Displays analgesic activity via desensitization of sensory neurons.2
The Uses of POLYGODIAL
Polygodial is a naturally occurring antifungal and antinociceptive.
What are the applications of Application
Polygodial is a naturally occurring antifungal and antinociceptive
Definition
ChEBI: Polygodial is an aldehyde.
Biochem/physiol Actions
Polygodial is a selective activator of Transient Receptor Potential Anykrin 1 (TRPA1) channels. Initially painful, polygodial acts as an analgesic by desensitizing sensory neuron. Polygodial also has broad antifungal properties, and is cytotoxic against bacteria and algae.
Storage
Store at -20°C
References
1) Escalera et al. (2008), TRPA1 mediates the noxious effects of natural sesquiterpene deterrents; J. Biol. Chem., 283 24136 2) Andre et al. (2004), Evidence for the involvement of vanilloid receptor in the antinociception produced by the dialdehydes unsaturated sesquiterpenes polygodial and drimanial in rats; Neuropharmacology, 46 590
Properties of POLYGODIAL
| Melting point: | 57° (Barnes, Loder) |
| Boiling point: | 330.7±35.0 °C(Predicted) |
| alpha | D24 -131° (c = 0.96 in ethanol) |
| Density | 1.084±0.06 g/cm3(Predicted) |
| RTECS | QJ2850000 |
| storage temp. | -20°C |
| solubility | DMSO: soluble20mg/mL, clear |
| form | powder |
| color | white to beige |
| Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months. |
Safety information for POLYGODIAL
Computed Descriptors for POLYGODIAL
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