Maleimide-PEG4-NHS Ester
Synonym(s):N-[15-[(2,5-Dioxo-1-pyrrolidinyl)oxy]-15-oxo-3,6,9,12-tetraoxapentadec-1-yl]-2,5-dihydro-2,5-dioxo-1H-pyrrole-1-propanamide;monodisperse Mal-PEG4-NHS-ester
- CAS NO.：756525-99-2
- Empirical Formula: C22H31N3O11
- Molecular Weight: 513.49
- MDL number: MFCD11041113
- EINECS: 201-258-5
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-07-23 14:48:42
What is Maleimide-PEG4-NHS Ester?
Description
Mal-amido-PEG4-NHS is a PEG linker containing a maleimide group and an NHS ester. The hydrophilic PEG spacer increases solubility in aqueous media. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol.
The Uses of Maleimide-PEG4-NHS Ester
Maleimide-PEG4-NHS (CAS# 756525-99-2) is a cross-linking compound used in the lysosomal acid-triggered release of anticancer drugs.
What are the applications of Application
monodisperse Mal-PEG4-NHS-ester is a monodispersed maleimide crosslinker with PEG spacers
Properties of Maleimide-PEG4-NHS Ester
| Density | 1.36±0.1 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | Soluble in DMSO |
| pka | 15.01±0.46(Predicted) |
| color | White to off-white |
Safety information for Maleimide-PEG4-NHS Ester
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for Maleimide-PEG4-NHS Ester
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