Nonaethylene glycol

CAS NO.：3386-18-3
Empirical Formula: C18H38O10
Molecular Weight: 414.49
MDL number: MFCD00698692
EINECS: 222-206-1
SAFETY DATA SHEET (SDS)
Update Date: 2026-05-28 02:11:23

What is Nonaethylene glycol?

Description

Nonaethylene glycol is a polymer consisting of ethylene glycol repeating units and terminal hydroxyl groups. The ethylene glycol units have high water solubility properties. The hydroxyl groups can react in order to further derivatize the compound.

The Uses of Nonaethylene glycol

HO-PEG9-OH is used as a reactant in the selective inhibition of human brain tumor cells through quantum-dot-based siRNA delivery.

Definition

ChEBI: Nonaethylene glycol is a poly(ethylene glycol).

Synthesis

Nonaethylene glycol could be synthesized by reacting the monosodium salt of triethylene glycol with the ditosylate of triethylene glycol [2] in solution in tetrahydrofuran. A small amount of less pure pentadecaethylene glycol was also isolated from the preparation[1].

References

[1] H. H. Teo, C. Booth, R. H. Mobbs. “Preparation of ethylene glycol oligomers—II.” European Polymer Journal 18 1 (1982): 541–544.

Properties of Nonaethylene glycol

Melting point:	24.0-25.2 °C
Boiling point:	190 °C(Press: 0.01 Torr)
Density	1.115±0.06 g/cm3(Predicted)
refractive index	1.46
Flash point:	26 °C
storage temp.	2-8°C
form	powder to lump
pka	14.06±0.10(Predicted)
color	White to Almost white
InChI	InChI=1S/C18H38O10/c19-1-3-21-5-7-23-9-11-25-13-15-27-17-18-28-16-14-26-12-10-24-8-6-22-4-2-20/h19-20H,1-18H2
EPA Substance Registry System	Nonaethylene glycol (3386-18-3)