Mal-PEG2-Val-Cit-amido-PAB-OH
- CAS NO.：2055041-38-6
- Empirical Formula: C29H42N6O9
- Molecular Weight: 618.68
- MDL number: MFCD29918233
- Update Date: 2026-05-28 02:10:35
What is Mal-PEG2-Val-Cit-amido-PAB-OH?
Description
Mal-PEG2-Val-Cit-PAB-OH is a cleavable ADC linker. The Val-Cit will specifically be cleaved by Cathepsin B. As this enzyme is only present in the lysosome, the ADC payload will be released only in the cell. The maleimide group is reactive toward thiol groups between pH 6.5 to 7.5. PEG chain increases the water solubility of the compound.
Properties of Mal-PEG2-Val-Cit-amido-PAB-OH
| Boiling point: | 948.4±65.0 °C(Predicted) |
| Density | 1.294±0.06 g/cm3(Predicted) |
| solubility | Soluble in DMSO, DMF |
| pka | 13.41±0.70(Predicted) |
Safety information for Mal-PEG2-Val-Cit-amido-PAB-OH
Computed Descriptors for Mal-PEG2-Val-Cit-amido-PAB-OH
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