Mal-PEG2-acid
- CAS NO.：1374666-32-6
- Empirical Formula: C11H15NO6
- Molecular Weight: 257.24
- MDL number: MFCD23726620
- Update Date: 2026-01-05 11:31:08
What is Mal-PEG2-acid?
Description
Mal-PEG2-acid is a PEG linker containing a maleimide group with a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.
Biological Activity
Mal-PEG2-acid is a non-cleavable ADC linker for the synthesis of antibody-drug conjugates (ADCs). It can bind to Tubulysin (HY-128914) and its cytotoxic derivatives activity. It can also be used as a PROTAC linker for PROTAC synthesis.
in vitro
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
Properties of Mal-PEG2-acid
| Boiling point: | 455.7±35.0 °C(Predicted) |
| Density | 1.329±0.06 g/cm3(Predicted) |
| form | powder to crystal |
| pka | 4.27±0.10(Predicted) |
| color | White to Light yellow |
| CAS DataBase Reference | 1374666-32-6 |
Safety information for Mal-PEG2-acid
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. |
Computed Descriptors for Mal-PEG2-acid
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