Magaldrate

Description

Magaldrate (hydroxymagnesium aluminate) insoluble in water, white, odorless crystalline powder, soluble in dilute mineral acids. Magaldrate favorably combines the strongly basic properties of magnesium located in the crystal core with the less basic properties of aluminum ions surrounding the former in a layered lattice. The magaldrate layered lattice consists of recurrent stacks of octahedral basic layers with an excess of positive charges 5+ on the outer gel surface , . These charges electrostatically interact with negative charges of the gastric mucus layer to favorably increase the antacid’s retention time in the stomach .

Chemical properties

White or almost white, crystalline powder.

The Uses of Magaldrate

Antacid.

Background

Magaldrate is an antacid drug used for the treatment of esophagitis, duodenal and gastric ulcers, and gastroesophageal reflux. Magaldrate has been discontinued in the US market.

brand name

Riopan (Whitehall-Robins).

Metabolism

Not Available